This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to TNFα and IL12, where IL12 was fused to the amino-terminus of the L19 scFv with one TNFα monomer fused to the carboxy-terminus of the (IL12)-scFv. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EDB as well as the biological activity of TNFα and IL12. This bi-antibody-cytokine fusion protein was active in vitro but it failed to localize in the tumors and exhibited limited therapeutic activity in immunocompetent 129sV mice bearing a sub cutaneous syngeneic F9 teratocarcinoma. This Immunocytokines was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-193 | Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | [(scFv - heavy - kappa) - IGHE - CH4]2 |
TAB-001CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (MOR03255) | ELISA, BL, IHC | Human antibody |
TAB-002CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (ME-4C) | ELISA, IHC | Human antibody |
TAB-003CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (1C5) | ELISA, WB | Human antibody |
TAB-004CQ-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (TAB-004CQ-S(P)) | ELISA, IHC, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1294z | Mouse Anti-FN1 Recombinant Antibody (clone 6H4) | IHC, IP, WB | Mouse IgG2b, κ |
HPAB-0193-CN | Mouse Anti-FN1 Recombinant Antibody (HPAB-0193-CN) | ELISA, FC, IHC | Mouse IgG1 |
HPAB-0194-CN | Mouse Anti-FN1 Recombinant Antibody (HPAB-0194-CN) | ELISA, FC, IHC | Mouse IgG1 |
HPAB-0195-CN | Human Anti-FN1 Recombinant Antibody (HPAB-0195-CN) | ELISA, FC, IHC | Humanized IgG |
HPAB-0196-CN | Human Anti-FN1 Recombinant Antibody (HPAB-0196-CN) | ELISA, FC, IHC | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-852CQ | Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) | ELISA, WB, IP, Block | Mouse IgG1 |
NEUT-853CQ | Mouse Anti-FN1 Recombinant Antibody (clone IST-9) | WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1326 | Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) | IHC-Fr, IHC-P, IHC-P, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0193-CN-S(P) | Mouse Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0193-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
HPAB-0194-CN-S(P) | Mouse Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0194-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
HPAB-0195-CN-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0195-CN-S(P)) | ELISA, FC, IHC | Human scFv |
HPAB-S0037-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); scFv Fragment | ELISA, IB, IHC | Human scFv |
HPAB-S0038-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone L19); scFv Fragment | ELISA, IF, IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1110-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1110-FY-S(P)) | IHC | Human scFv |
HPAB-1111-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1111-FY-S(P)) | IHC | Human scFv |
HPAB-1112-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1112-FY-S(P)) | IHC | Human scFv |
HPAB-1113-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1113-FY-S(P)) | IHC | Human scFv |
HPAB-1114-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1114-FY-S(P)) | IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NBD-0040-YJ-VHH | Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) | ELISA, In vivo imaging | Camelid VHH |
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