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Mouse Anti-EDN1 Recombinant Antibody (clone TR.ET.48.5) (CAT#: NEUT-717CQ)

This antibody is a mouse monoclonal antibody that binds specifically to Endothelin 1, and it can neutralize the bioactivity of Endothelin 1.


See more Engineered Antibody products for EDN1
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  • Gene Expression
  • Datasheet
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nucleoli & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/if_selected.jpg
Figure 2 IHC staining of human colon
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells and endothelial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/66918_A_9_3_selected.jpg
Figure 3 IHC staining of human colon
Figure 3 IHC staining of human colon
(Immunohistochemical staining of human colon shows plasma positivity in blood vessels.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_8_3_selected.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nucleoli & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/321_D9_7_blue_red_green.jpg
Figure 5 IF staining of human cell line U-251 MG
Figure 5 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nucleoli & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31976/323_D9_1_blue_red_green.jpg
Normal Tissue
Figure 6 Lung
Figure 6 Lung
(Alveolar cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Macrophages
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_1_4.jpg
Figure 7 Colon
Figure 7 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_8_3.jpg
Figure 8 Liver
Figure 8 Liver
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_8_4.jpg
Figure 9 Kidney
Figure 9 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_9_5.jpg
Figure 10 Testis
Figure 10 Testis
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37291/87377_A_6_6.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, T-47d, TIME)
Figure 11 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, T-47d, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000078401-EDN1

Specifications

  • Immunogen
  • The immunogen corresponding to a region within amino acids 60 and 68 of human ET-1
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • Human EDN1
  • Species Reactivity
  • Human, Mouse, Canine, Porcine, Rat, Rabbit, Sheep
  • Clone
  • TR.ET.48.5
  • Applications
  • Block, ELISA, FC, ICC, IF, IHC, IHC-Fr, IHC-P, IP, RIA, WB
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Purified with affinity chromatography
  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • EDN1; endothelin 1; ET1; QME; PPET1; ARCND3; HDLCQ7

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "EDN1"

Single-domain Antibody

CAT Product Name Application Type
NAB-818-VHH Recombinant Anti-Human EDN1 VHH Single Domain Antibody FA, FC, ICC, ELISA Llama VHH

Fab Fragment Antibody

CAT Product Name Application Type
DrMAB-1051 Mouse Anti-EDN1 Recombinant Antibody (clone YC038); Fab Fragment ELISA, LMNX Mouse Fab

Recombinant Antibody

CAT Product Name Application Type
MOB-0658CT Recombinant Mouse anti-Human EDN1 Monoclonal antibody (2D20) ELISA

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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