Products

Anti-EGFR Immunocytokine, TNF-IgG (mAb 425) (ACFP-SH080)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EGFR IgG to TNFα. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EGFR as well as the biological activity of TNFα. The fusion protein supported mainly proliferation and lymphokine-activated killer cell activity, and TNF-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytokine was designed for treating any type of solid or non-solid cancer or malignant lymphoma.      

Specifications
Target
EGFR
Molecule Class
TNF-IgG2a
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
mAb 425
Related Disease
Any type of solid or non-solid cancer or malignant lymphoma
Cytokines 1
TNFα
Cytokines 1 Description
Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia. The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers. Both the mature protein and a partially processed form of the hormone can be secreted after cleavage of the propeptide.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog); ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40
Entrez Gene ID
1956
UniProt ID
P00533

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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