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anti-EPCAM immunotoxin MOC31 (IgG)-DT (CAT#: AGTO-L013D)

This immunotoxin was achieved by conjugating/fusing the Anti-EPCAM monoclonal antibody to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to carcinoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of cancers.


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Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67463/1592_H11_2_selected.jpg
Normal Tissue
Figure 2 Thyroid gland
Figure 2 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_B_2_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • MOC31
  • Molecule Class
  • L kappa; IgG1-DT
  • Toxin Description
  • Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Hepatocellular carcinomas (HCC)

Target

  • Alternative Names
  • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); Hepatocellular carcinomas; HCC; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1093z Mouse Anti-EPCAM Recombinant Antibody (clone 41D5) WB, FC, IHC, IP, FuncS Mouse IgG1, κ
MOB-0093MZ Recombinant Mouse Anti-Ep-CAM Antibody (clone IEA126) IHC, WB, IF Mouse antibody
FAMAB-0129CQ Human Anti-EPCAM Recombinant Antibody (clone 17-1A) ELISA, IHC, FC Chimeric (mouse/human) IgG
FAMAB-0130CQ Human Anti-EPCAM Recombinant Antibody (clone 323/A3) ELISA, IHC, FC Chimeric (mouse/human) IgG
FAMAB-0131CQ Mouse Anti-EPCAM Recombinant Antibody (clone MOC-161) ELISA, IHC, FC Mouse IgG2a, κ

Humanized Antibody

CAT Product Name Application Type
TAB-112-F(E) Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) Neut, ELISA, IF, IP, FuncS, FC, ICC Fab - G1 - kappa
TAB-362MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (3622W94) Confocal, ELISA Humanized antibody
TAB-374MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (h12H8B) FC, ELISA Humanized antibody
TAB-375MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (h12H8C) FC, ELISA Humanized antibody
TAB-376MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (h2D11B) FC, ELISA Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L013E anti-EPCAM immunotoxin MOC31 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L013G anti-EPCAM immunotoxin MOC31 (IgG)-Gel Cytotoxicity assay, Functional assay
AGTO-L013R anti-EPCAM immunotoxin MOC31 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L013O anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin Cytotoxicity assay, Functional assay

Mouse Antibody

CAT Product Name Application Type
TAB-0531CL Anti-Human EPCAM Recombinant Antibody (HE2) ELISA, Inhib
TAB-363MZ Mouse Anti-EPCAM Recombinant Antibody (TAB-363MZ) ELISA, FuncS Mouse IgG1, κ
TAB-364MZ Mouse Anti-EPCAM Recombinant Antibody (TAB-364MZ) FC Mouse IgG1
TAB-365MZ Mouse Anti-EPCAM Recombinant Antibody (TAB-365MZ) FC Mouse IgG1
TAB-366MZ Mouse Anti-EPCAM Recombinant Antibody (TAB-366MZ) ELISA, FC Mouse IgG

Human Antibody

CAT Product Name Application Type
TAB-356MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (3-171) FC, ELISA Human antibody
TAB-357MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (7-F17) FC, ELISA Human antibody
TAB-358MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (12-C15) FC, ELISA Human antibody
TAB-359MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (16-G5) FC, ELISA Human antibody
TAB-360MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (17-C20) FC, ELISA Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1163 Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) IHC-P, WB, ICC, ICC, IF Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0163CQ-F(E) Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54); Fab Fragment ELISA, FC, FuncS Human Fab
HPAB-2216LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) ELISA Human Fab
HPAB-2217LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) ELISA Human Fab
HPAB-2218LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) ELISA Human Fab
HPAB-2219LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) ELISA Human Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-106 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody
AFC-TAB-213 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS ADCC enhanced antibody
AFC-TAB-701 Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-2234LY-S(P) Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2234LY-S(P)) ELISA Human scFv
HPAB-1520-FY-F(E) Mouse Anti-EPCAM Recombinant Antibody (clone 2A9); scFv Fragment ELISA, FC Mouse scFv
HPAB-1521-FY-F(E) Mouse Anti-EPCAM Recombinant Antibody (clone FMU-EPCAM-4E4); scFv Fragment ELISA, FC Mouse scFv
HPAB-1522-FY-F(E) Mouse Anti-EPCAM Recombinant Antibody (clone FMU-EPCAM-4F6); scFv Fragment ELISA, FC Mouse scFv
HPAB-S0026-YC-S(P) Human Anti-EPCAM Recombinant Antibody (clone H79); scFv Fragment ELISA, FC, Cyt Human scFv

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN0031 APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer FCM
MHC-CN0032 PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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