Human Anti-EPOR Recombinant Antibody (clone ABT-007) (CAT#: PABW-040)
Recombinant Human Antibody (ABT-007) is capable of binding to EPOR, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-EPOR mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-EPOR mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 ABT007 stimulates in vitro erythropoiesis.
(A) ABT007 stimulates the proliferation of EPO-responsive F36E human erythroleukemic cells. Error bars represent standard deviation (SD) calculated from the average of duplicate counts. (B) ABT007 supports the formation of erythroid colonies from hematopoietic precursor cells. Error bars represent standard deviation (SD) calculated from the average of duplicate counts. Typical colonies, identified microscopically, are shown below for (C) the isotype control–, (D) EPO-, and (E) ABT007-treated cells. The colonies were red in color.
Liu, Z., Stoll, V. S., DeVries, P. J., Jakob, C. G., Xie, N., Simmer, R. L., ... & Reilly, E. B. (2007). A potent erythropoietin-mimicking human antibody interacts through a novel binding site. Blood, 110(7), 2408-2413.
Specifications
- Immunogen
- Human erythropoietin receptor
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human EPOR
- Species Reactivity
- Human
- Clone
- ABT-007
- Applications
- WB, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The EPOR antibody has been reported in applications of Stimulation.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007); scFv Fragment | WB, FuncS | Human scFv |
| HPAB-0169CQ-S(P) | Human Anti-EPOR Recombinant Antibody (clone ABT2-SCX-012); scFv Fragment | Agonist, ELISA | Human scFv |
| HPAB-1306WJ-S(P) | Mouse Anti-EPOR Recombinant Antibody (clone 3G9); scFv Fragment | ELISA, WB, Agonist | Mouse scFv |
| HPAB-1849-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab12); scFv Fragment | Activ | Human scFv |
| HPAB-1850-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab198); scFv Fragment | Activ | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
| TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008WM | Anti-Human EPOR Recombinant Antibody (1E3) | ELISA, WB, FC | |
| TAB-009WM | Mouse Anti-EPOR Recombinant Antibody (TAB-009WM) | WB, FC | Mouse IgG |
| TAB-008WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (1E3) | ELISA, WB, FC | |
| TAB-009WM-S(P) | Mouse Anti-EPOR Recombinant Antibody; scFv Fragment (TAB-009WM-S(P)) | WB, FC | Mouse scFv |
| TAB-008WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (1E3) | ELISA, WB, FC |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-736CQ | Mouse Anti-EPOR Recombinant Antibody (clone CBL641) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1173 | Hi-Affi™ Rabbit Anti-EPOR Recombinant Antibody (clone DS1173AB) | IP, WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0490-CN | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1) | ELISA, WB, ICC, IHC, IP | Mouse IgG |
| HPAB-0491-CN | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2) | ELISA, WB, ICC, IHC, IP | Mouse IgG |
| HPAB-1692-FY | Recombinant Human Anti-EPOR Antibody (Ab12) | Activ, FC, ELISA | Human IgG1 |
| HPAB-1693-FY | Human Anti-EPOR Recombinant Antibody (clone Ab12.6) | FC, ELISA | Human IgG1 |
| HPAB-1694-FY | Human Anti-EPOR Recombinant Antibody (clone Ab12.56) | FC, ELISA | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0490-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
| HPAB-0491-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 19.1.2); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
| HPAB-0169CQ-F(E) | Human Anti-EPOR Recombinant Antibody (clone ABT2-SCX-012); Fab Fragment | Agonist, ELISA | Human Fab |
| HPAB-0359-YJ-F(E) | Human Anti-EPOR Recombinant Antibody; Fab Fragment (HPAB-0359-YJ-F(E)) | ELISA, FC, Activ, FuncS | Human Fab |
| HPAB-0360-YJ-F(E) | Human Anti-EPOR Recombinant Antibody; Fab Fragment (HPAB-0360-YJ-F(E)) | ELISA, FC, Activ, FuncS | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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