Mouse Anti-ERBB3 Recombinant Antibody (clone 12511) (CAT#: HPAB-0289-YC)
The anti-human erbB3 monoclonal antibody clone 12511 binds with both human erbB3 and mouse erbB3. ERBB3 is a single pass type transmembrane protein which belongs to epidermal growth factor receptor (EGFR) family.
Specific Inquiry
FuncS
Figure 1 shows the antitumor effect of the anti-human erbB3 antibody in a human breast cancer cell line T47D-grafted mouse model.
The abscissa shows the number of days after the tumor grafting, and the ordinate shows the tumor volume. "□" indicates an anti-DNP antibody as a control, "♦" indicates a 1153 antibody, "∘" indicates a 12511 antibody, "X" indicates a 920104 antibody, "Δ" indicates a 1126 antibody, and "●" indicates a U1-59 antibody.
FuncS
Figure 2 shows combinational effect of the anti-human erbB3 antibodies in the human squamous carcinoma cell line A431-grafted mouse model.
"□" indicates an anti-DNP antibody as a control, "♦" indicates a 1153+1251 combination antibody (combination antibody of a 1153 antibody and a 12511 antibody), "∘" indicates a 12511+1126 combination antibody (combination antibody of a 12511 antibody and a 1126 antibody), and "X" indicates a 1153+1126 combination antibody (combination antibody of a 1153 antibody and a 1126 antibody). The abscissa shows the number of days after the tumor grafting, and the ordinate shows the tumor volume.
Specifications
- Immunogen
- ErbB3-Fc
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ERBB3
- Species Reactivity
- Human, Mouse
- Clone
- 12511
- Applications
- ELISA, FuncS, FC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Enzyme-linked Immunosorbent Assay, Flow Cytometry, and Functional Assay. For details, refer to Published Data.
Target
- Alternative Names
- Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; P180-ErbB3; P45-SErbB3; P85-SErbB3; EC 2.7.10; MDA-BF-1; C-ErbB-3; C-ErbB3; ErbB3-S; ErbB-3; LCCS2
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 12511"
See other products for "ERBB3"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (BCD090-M2) | ELISA, SPR | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-892 | Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG2 - lambda |
| TAB-H22 | Anti-Human ERBB3 Recombinant Antibody (Duligotuzumab) (TAB-H22) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-059CT | Anti-Human HER3 Recombinant Antibody (LMAb3) | WB, ELISA, Inhibition, FC | Humanized antibody |
| TAB-063CT | Human Anti-ERBB3 Recombinant Antibody (TAB-063CT) | IF, WB, Inhib, ELISA | Humanized antibody |
| TAB-057CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-057CT-S(P)) | Inhibion, ELISA | Humanized scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H47 | Anti-Human ERBB3 Recombinant Antibody (Lumretuzumab) | ELISA, Inhib | Human IgG1, κ |
| MOB-0309MZ | Recombinant Mouse Anti-Human ERBB3 Antibody (clone EAK-H4-IC) | IHC | Mouse antibody |
| HPAB-0022-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0022-WJ) | ELISA, Inhib, WB, FuncS | Human IgG1, λ |
| HPAB-0024-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0024-WJ) | ELISA | Human IgG1 |
| HPAB-0025-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0025-WJ) | ELISA | Human IgG1 |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0508CL | Anti-Human ERBB3 Recombinant Antibody (1A5) | ELISA, FC, Inhib, FuncS | |
| TAB-0509CL | Anti-Human ERBB3 Recombinant Antibody (3D4) | Inhib, FC | |
| TAB-0552CL | Mouse Anti-ERBB3 Recombinant Antibody (TAB-0552CL) | ELISA, Inhib | Mouse IgG |
| TAB-0553CL | Mouse Anti-ERBB3 Recombinant Antibody (TAB-0553CL) | ELISA, Inhib | Mouse IgG |
| TAB-060CT | Rabbit Anti-ERBB3 Recombinant Antibody (TAB-060CT) | Inhib, ELISA | Rabbit IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0051CL-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-0051CL-S(P)) | ELISA, FuncS, Inhib, FC | Human scFv |
| TAB-0052CL-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-0052CL-S(P)) | ELISA, FuncS, Inhib, FC | Human scFv |
| TAB-062CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-062CT-F(E)) | ELISA, Inhib, FC | Human Fab |
| TAB-065CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-065CT-F(E)) | ELISA, FC | Human Fab |
| TAB-066CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-066CT-F(E)) | ELISA, Inhibion, FC | Human Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
| TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
| TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
| NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
| NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
| NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone M908) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0286-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0287-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0288-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1126); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0289-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 12511); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0290-YC-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0290-YC-F(E)) | ELISA, FuncS, FC | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
| AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0721-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0721-WJ-S(P)) | ELISA | Human scFv |
| HPAB-1695-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-1695-FY-F(E)) | ELISA | Human Fab |
| HPAB-1696-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-1696-FY-F(E)) | ELISA | Human Fab |
| FAMAB-0047JF-S(P) | Human Anti-ERBB3 Recombinant Antibody (clone PM6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBS-0069 | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBS-0069) | ELISA, Block, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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