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  • Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB)

Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) (CAT#: MOR-1179)

Recombinant Rabbit anti-ERBB3 monoclonal antibody for ICC/IF, WB, excellent for producing superior results. Hi-Affi™ antibodies are developed from different sources, such as B cells of immunized animals, hybridoma, phage display library. The application of recombinant technology avoids the traditional ascitic fluid approach, which achieves the antibody generation in a humane way with much larger scale, greater specificity and sensitivity, and not susceptible to cell-line drift or lot-to-lot variation.


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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/if_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/ihc_selected.jpg
Figure 3 IHC staining of human small intestine
Figure 3 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70524/162441_A_4_2_selected.jpg
Figure 4 IHC staining of human kidney
Figure 4 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in renal tubular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_8_5_selected.jpg
Figure 5 IF staining of human cell line A-431
Figure 5 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/659_B11_4_blue_red_green.jpg
Figure 6 IF staining of human cell line U-251 MG
Figure 6 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/658_B11_1_blue_red_green.jpg
Normal Tissue
Figure 7 Cerebral cortex
Figure 7 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_7_5.jpg
Figure 8 Colon
Figure 8 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_9_3.jpg
Figure 9 Liver
Figure 9 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_8_4.jpg
Figure 10 Kidney
Figure 10 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_5.jpg
Figure 11 Testis
Figure 11 Testis
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_4_6.jpg
Figure 12 Skin
Figure 12 Skin
(Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Langerhans
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Melanocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_8_1.jpg
Figure 13 Lymph node
Figure 13 Lymph node
(Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_8.jpg
RNA Expression
Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)
Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000065361-ERBB3

Specifications

  • Immunogen
  • A phospho-specific peptide corresponding to residues surrounding Tyrosine 1289 of Human ErbB 3.
  • Host Species
  • Rabbit
  • Derivation
  • Phage display library
  • Type
  • Rabbit IgG
  • Specificity
  • Human ERBB3
  • Species Reactivity
  • Human
  • Clone
  • DS1179AB
  • Applications
  • ICC, IF, WB
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Purified with Absolute Mag™ Protein A Agarose
  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; P180-ErbB3; P45-SErbB3; P85-SErbB3; EC 2.7.10; MDA-BF-1; C-ErbB-3; C-ErbB3; ErbB3-S; ErbB-3; LCCS2

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "ERBB3"

Single-domain Antibody

CAT Product Name Application Type
NAB-1729-sdAb Recombinant Anti-human ERBB3 VHH Single Domain Antibody WB, ICC, ChiP, FA, ELISA Llama VHH
TAB-070CT Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) FC, Block Llama VHH
PABC-556 Recombinant Llama Anti-ERBB3 Single Domain Antibody (BCD090-M2) ELISA, SPR Llama VHH

Recombinant Antibody

CAT Product Name Application Type
TAB-H47 Anti-Human ERBB3 Recombinant Antibody (Lumretuzumab) ELISA, Inhib Human IgG1, κ
MOB-0309MZ Recombinant Mouse Anti-Human ERBB3 Antibody (clone EAK-H4-IC) IHC Mouse antibody
HPAB-0022-WJ Human Anti-ERBB3 Recombinant Antibody (HPAB-0022-WJ) ELISA, Inhib, WB, FuncS Human IgG1, λ
HPAB-0024-WJ Human Anti-ERBB3 Recombinant Antibody (HPAB-0024-WJ) ELISA Human IgG1
HPAB-0025-WJ Human Anti-ERBB3 Recombinant Antibody (HPAB-0025-WJ) ELISA Human IgG1

Immunotoxin

CAT Product Name Application Type
AGTO-L074E HRGβ2-PE immunotoxin Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-0053CL Human Anti-ERBB3 Recombinant Antibody (TAB-0053CL) ELISA, FuncS, Inhib, FC Human IgG
TAB-0054CL Human Anti-ERBB3 Recombinant Antibody (TAB-0054CL) ELISA, FuncS, Inhib, FC Human IgG
TAB-0055CL Human Anti-ERBB3 Recombinant Antibody (TAB-0055CL) ELISA, FuncS, Inhib, FC Human IgG
TAB-065CT-F(E) Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-065CT-F(E)) ELISA, FC Human Fab
TAB-066CT-F(E) Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-066CT-F(E)) ELISA, Inhibion, FC Human Fab

Mouse Antibody

CAT Product Name Application Type
TAB-0508CL Anti-Human ERBB3 Recombinant Antibody (1A5) ELISA, FC, Inhib, FuncS
TAB-0509CL Anti-Human ERBB3 Recombinant Antibody (3D4) Inhib, FC
TAB-0552CL Mouse Anti-ERBB3 Recombinant Antibody (TAB-0552CL) ELISA, Inhib Mouse IgG
TAB-0553CL Mouse Anti-ERBB3 Recombinant Antibody (TAB-0553CL) ELISA, Inhib Mouse IgG
TAB-060CT-F(E) Rabbit Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-060CT-F(E)) Inhib, ELISA Rabbit Fab

Humanized Antibody

CAT Product Name Application Type
TAB-057CT Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) Inhibion, ELISA Humanized antibody
TAB-059CT Anti-Human HER3 Recombinant Antibody (LMAb3) WB, ELISA, Inhibition, FC Humanized antibody
TAB-063CT-S(P) Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-063CT-S(P)) ELISA, Inhib, FC Human scFv
TAB-058CT-F(E) Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-058CT-F(E)) WB, ELISA, Inhib Humanized Fab
TAB-059CT-F(E) Anti-Human HER3 Recombinant Antibody Fab Fragment (LMAb3) WB, ELISA, Inhibition, FC Humanized antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-061CT Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) Inhib, ELISA Chimeric (Rabbit/Human) antibody
TAB-061CT-S(P) Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) Inhib, ELISA Human scFv
TAB-061CT-F(E) Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) Inhib, ELISA Chimeric (Rabbit/Human) Fab

Neutralizing Antibody

CAT Product Name Application Type
NEUT-738CQ Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) Neut, IP Mouse IgG1
NEUT-739CQ Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) FC, CyTOF®, ELISA, Neut Mouse IgG1
NEUT-740CQ Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) Neut Human IgG1, κ
NEUT-741CQ Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) Neut Human IgG1, κ
NEUT-742CQ Mouse Anti-ERBB3 Recombinant Antibody (clone M908) Neut Mouse IgG1

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0286-YC-F(E) Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); Fab Fragment ELISA, FuncS, FC Mouse Fab
HPAB-0287-YC-F(E) Mouse Anti-ERBB3 Recombinant Antibody (clone 920104); Fab Fragment ELISA, FuncS, FC Mouse Fab
HPAB-0288-YC-F(E) Mouse Anti-ERBB3 Recombinant Antibody (clone 1126); Fab Fragment ELISA, FuncS, FC Mouse Fab
HPAB-0289-YC-F(E) Mouse Anti-ERBB3 Recombinant Antibody (clone 12511); Fab Fragment ELISA, FuncS, FC Mouse Fab
HPAB-0290-YC-F(E) Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0290-YC-F(E)) ELISA, FuncS, FC Human Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H21 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-422CQ Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, BL ADCC enhanced antibody
AFC-TAB-189 Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA Human IgG1, κ
AFC-TAB-H22 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-892 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0436-FY-S(P) Mouse Anti-ERBB3 Recombinant Antibody (clone 15D5); scFv Fragment Inhib Mouse scFv
HPAB-0437-FY-S(P) Mouse Anti-ERBB3 Recombinant Antibody (clone 1D9); scFv Fragment Inhib Humanized scFv
HPAB-0438-FY-S(P) Mouse Anti-ERBB3 Recombinant Antibody (clone 993); scFv Fragment FC, Inhib Mouse scFv
FAMAB-0047JF-S(P) Human Anti-ERBB3 Recombinant Antibody (clone PM6); scFv Fragment WB, ELISA, FuncS Human scFv
PSBS-0069 Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBS-0069) ELISA, Block, FuncS Human scFv

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