Products

Anti-EpCAM Immunocytokine, GM-CSF-FAB (L19) (ACFP-SH049)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM FAB to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of GM-CSF. This fusion protein was directed against EpCAM and induced tumor cell lysis in vitro, which was dependent on the presence of the cytokine. Thus, GM-CSF activated PBMCs to lyse tumor cells, while IL-2 redirected lysis by T cells. This immunocytokine was designed for treating solid tumor.      

Specifications
Target
EpCAM
Molecule Class
GM-CSF-FAB
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
L19
Related Disease
Solid tumors
Cytokines 1
GM-CSF
Cytokines 1 Description
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
Entrez Gene ID
4072
UniProt ID
P16422

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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