Products

Anti-EpCAM Immunocytokine, IgG (KS-1/4)-IL12 (ACFP-SH167)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL12. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of IL12. Hybrid IL12 fusion proteins composed of mouse p35 and human p40, fused to Ab, were capable of inducing IFN-γ, but were much less active on mouse spleen cells than a mouse IL12 standard. Despite this relatively low activity, the hybrid fusion protein was as effective in a SCID mouse model as a fully active Ab-IL2 fusion protein in eliminating established pulmonary metastases of CT26 colon carcinoma. This Immunocytokines was designed for treating solid tumor.      

Specifications
Target
EpCAM
Molecule Class
IgG1-IL12
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
KS-1/4
Related Disease
Solid tumor
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Mouse
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
Entrez Gene ID
4072
UniProt ID
P16422

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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