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Anti-EpCAM Immunocytokine, IgG (KS)-IL2 (ACFP-SH148)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL2 and scIL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2 and scIL12. This bi-antibody-cytokine fusion protein showed effective antigen binding and cytokine activity. KS-(IL12/IL2) exhibits significant antitumor activity, similar to that observed when the combination of KS-(IL2) and KS-(IL12) was used. This immunocytokine was designed for treating solid tumor.      

Specifications
Target
EpCAM
Molecule Class
IgG1-scIL12-IL2
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
KS
Related Disease
Solid tumor
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
Entrez Gene ID
4072
UniProt ID
P16422

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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