Products

Anti-EpCAM Immunocytokine, IgG-ala (huKS)-IL2 (N88R) (ACFP-SH073)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG-ala to IL2 (N88R). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2 (N88R). This huKS-IL2 variant contains the same amino acid substitution at the junction between the Ig heavy chain constant region and mature huIL2 (K-A, created by the codon change AAA to GCC), and in addition it contains a substitution at position N88 in the sequence of mature huIL2 in favor of R (created by codon change aAT to aGG). This immunocytokine was designed for treating solid tumor.      

Specifications
Target
EpCAM
Molecule Class
L Kappa; IgG4-ala-IL2 (N88R)
Species Reactivity
Human
Host
Humanized from Mouse
Expression Host
CHO
Clone
huKS
Related Disease
Solid tumors
Cytokines 1
IL2 (N88R)
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
Entrez Gene ID
4072
UniProt ID
P16422

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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