This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM scFv-CH1; scFv-Cκ to IL2 and GM-CSF. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of IL2 and GM-CSF. These bi-antibody-cytokine fusion proteins exhibited the ability to bind the targeted antigen and retained the biological activity of murine IL-2 and GM-CSF to induce CTLL-2 and FDC-P1 cell proliferation respectively. The mDCH-3B10 fusion protein, tested by a systemic treatment with the bi-antibody-cytokine fusion protein, induced significant inhibition of pulmonary metastases of mouse colon carcinoma CT26 expressing human KSA (CT26-KSA) cells in immunocompetent BALB/c mice. This Immunocytokines was designed for treating EpCAM over-expressing cancers.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-213 | Humanized Anti-EPCAM Recombinant Antibody (clone Tucotuzumab) | WB, Neut, ELISA, IF, IP, FuncS, FC | Humanized (from mouse) IgG1 |
TAB-112-F(E) | Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Fab - G1 - kappa |
TAB-235CL | Human Anti-Human EPCAM Recombinant Antibody (3622W94) | Cyt, FC | Antibody |
TAB-362MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (3622W94) | Confocal, ELISA | Humanized antibody |
TAB-374MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (h12H8B) | FC, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-106 | Anti-Human EPCAM Recombinant Antibody (Adecatumumab) | FC, IHC, FuncS, Inhib, Cyt | IgG1 |
TAB-356MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (3-171) | FC, ELISA | Human antibody |
TAB-357MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (7-F17) | FC, ELISA | Human antibody |
TAB-358MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (12-C15) | FC, ELISA | Human antibody |
TAB-359MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (16-G5) | FC, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L013E | anti-EPCAM immunotoxin MOC31 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L013D | anti-EPCAM immunotoxin MOC31 (IgG)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L013G | anti-EPCAM immunotoxin MOC31 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L013R | anti-EPCAM immunotoxin MOC31 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L013O | anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-363MZ-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-363MZ-S(P)) | Confocal, ELISA | Mouse scFv |
TAB-364MZ-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-364MZ-S(P)) | NIR (Near-infrared) fluorescence imaging, ELISA | Mouse scFv |
TAB-365MZ-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-365MZ-S(P)) | NIR (Near-infrared) fluorescence imaging, ELISA | Mouse scFv |
TAB-366MZ-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-366MZ-S(P)) | ELISA, WB, IHC | Mouse scFv |
TAB-367MZ-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-367MZ-S(P)) | ELISA, WB, IHC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0093MZ | Recombinant Mouse Anti-Ep-CAM Antibody (clone IEA126) | IHC, WB, IF | Mouse antibody |
HPAB-0163CQ | Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54) | ELISA, FC, FuncS | Human IgG1 |
MRO-0537-CN | Rabbit Anti-EPCAM Recombinant Antibody (clone CBACN-213) | WB, IHC | Rabbit IgG |
MRO-0538-CN | Mouse Anti-EPCAM Recombinant Antibody (clone 3-E1-E2) | WB, IF, IHC, FC | Mouse IgM |
MRO-1842-CN | Rabbit Anti-EPCAM Polyclonal Antibody (MRO-1842-CN) | WB, IF, IHC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1163 | Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) | IHC-P, WB, ICC, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0129CQ-F(E) | Human Anti-EPCAM Recombinant Antibody (clone 17-1A); Fab Fragment | ELISA, IHC, FC | Chimeric (mouse/human) Fab |
FAMAB-0130CQ-F(E) | Human Anti-EPCAM Recombinant Antibody (clone 323/A3); Fab Fragment | ELISA, IHC, FC | Chimeric (mouse/human) Fab |
FAMAB-0131CQ-F(E) | Mouse Anti-EPCAM Recombinant Antibody (clone MOC-161); Fab Fragment | ELISA, IHC, FC | Mouse Fab |
HPAB-2216LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) | ELISA | Human Fab |
HPAB-2217LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0163CQ-S(P) | Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54); scFv Fragment | ELISA, FC, FuncS | Human scFv |
HPAB-0428-FY-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-0428-FY-S(P)) | ELISA | Mouse scFv |
HPAB-S0026-YC-S(P) | Human Anti-EPCAM Recombinant Antibody (clone H79); scFv Fragment | ELISA, FC, Cyt | Human scFv |
HPAB-2050-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone K53); scFv Fragment | FC | Human scFv |
HPAB-2051-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone 02-237); scFv Fragment | FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-106 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-213 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS | ADCC enhanced antibody |
AFC-TAB-701 | Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0031 | APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM | |
MHC-CN0032 | PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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