Anti-EpCAM Antibody-Cytokine Fusion Protein, scIL12-linker-IgG (KS)-IL2 (CAT#: ACFP-SH149)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL2. It was expressed in CHO and purified with affinity chromatography. This bi-antibody-cytokine fusion protein showed effective antigen binding and cytokine activity. IL12-KS-IL2 exhibits significant antitumor activity, similar to that observed when the combination of KS-(IL2) and KS-(IL12) was used. This immunocytokine was designed for treating solid tumor.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • EpCAM
  • Molecule Class
  • scIL12-linker-IgG1-IL2
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • KS
  • Related Disease
  • Solid tumor
  • Cytokine 1
  • IL2
  • Cytokines 1 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component; chromosome 4; surface marker (35kD glycoprotein)

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone KS"

See other products for "EPCAM"

Mouse Antibody

CAT Product Name Application Type
TAB-701 Anti-Human EpCAM/17-1A Recombinant Antibody (Edrecolomab) ELISA, IP, FC, FuncS, IF, Neut IgG2a - kappa
TAB-0531CL Anti-Human EPCAM Recombinant Antibody (HE2) ELISA, Inhib
TAB-363MZ-F(E) Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-363MZ-F(E)) Confocal, ELISA Mouse Fab
TAB-364MZ-F(E) Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-364MZ-F(E)) NIR (Near-infrared) fluorescence imaging, ELISA Mouse Fab
TAB-365MZ-F(E) Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-365MZ-F(E)) NIR (Near-infrared) fluorescence imaging, ELISA Mouse Fab

Humanized Antibody

CAT Product Name Application Type
TAB-213 Humanized Anti-EPCAM Recombinant Antibody (clone Tucotuzumab) WB, Neut, ELISA, IF, IP, FuncS, FC Humanized (from mouse) IgG1
TAB-235CL Human Anti-Human EPCAM Recombinant Antibody (3622W94) Cyt, FC Antibody
TAB-374MZ Anti-Human EPCAM Recombinant Antibody (h12H8B) FC, ELISA Humanized antibody
TAB-375MZ Anti-Human EPCAM Recombinant Antibody (h12H8C) FuncS, Inhib Humanized antibody
TAB-376MZ Anti-Human EPCAM Recombinant Antibody (h2D11B) Cyt, Inhib Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L013E anti-EPCAM immunotoxin MOC31 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L013D anti-EPCAM immunotoxin MOC31 (IgG)-DT Cytotoxicity assay, Functional assay
AGTO-L013G anti-EPCAM immunotoxin MOC31 (IgG)-Gel Cytotoxicity assay, Functional assay
AGTO-L013R anti-EPCAM immunotoxin MOC31 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L013O anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin Cytotoxicity assay, Functional assay

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1163 Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) IHC-P, WB, ICC, ICC, IF Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-106 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody
AFC-TAB-213 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS ADCC enhanced antibody
AFC-TAB-701 Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for ACFP-SH149. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare