Products

Anti-EpCAM Immunocytokine, scIL12-linker-IgG (KS)-IL2 (ACFP-SH149)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL2. It was expressed in CHO and purified with affinity chromatography. This bi-antibody-cytokine fusion protein showed effective antigen binding and cytokine activity. IL12-KS-IL2 exhibits significant antitumor activity, similar to that observed when the combination of KS-(IL2) and KS-(IL12) was used. This immunocytokine was designed for treating solid tumor.      

Specifications
Target
EpCAM
Molecule Class
scIL12-linker-IgG1-IL2
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
KS
Related Disease
Solid tumor
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
Entrez Gene ID
4072
UniProt ID
P16422

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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