Anti-FAP Antibody-Cytokine Fusion Protein, IgG (4B9)-IL10 (CAT#: ACFP-SH008)

This antibody-cytokine fusion protein was achieved by conjugating/fusing IL10 (wild type human IL10 cytokine sequence) to C-terminus of IgG heavy chain (with engineered Fc-region to avoid effector functions). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the FAP as well as the biological activity of IL10. This immunocytokine was designed for treating inflammatory diseases.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Target
  • FAP
  • Molecule Class
  • IgG1-IL10
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • 4B9
  • Related Disease
  • inflammatory diseases
  • Cytokine 1
  • IL10
  • Cytokines 1 Description
  • Viral interleukin-10 has now been termed viral interleukin 10 (vlL-10) to reflect its protein sequence homology to "cellular" IL10 (cIL10, either murine or human IL10). It is now widely accepted that vlL-10 shares many functions with clL-10, principally, the ability to enhance survival of newly infected B cells and to diminish the production of IFN-β and IL-2 during ongoing immune reactions.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • FAP; fibroblast activation protein; alpha; FAPA; SIMP; DPPIV; prolyl endopeptidase FAP; seprase; FAPalpha; dipeptidyl peptidase FAP; surface-expressed protease; post-proline cleaving enzyme; gelatine degradation protease FAP; integral membrane serine protease; serine integral membrane protease; 170 kDa melanoma membrane-bound gelatinase

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 4B9"

See other products for "Fap"

Humanized Antibody

CAT Product Name Application Type
TAB-211 Anti-Human FAP Recombinant Antibody (Sibrotuzumab) ELISA, IP, FC, FuncS, Neut, IF, WB IgG1 - kappa

Single-domain Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-211 Afuco™ Anti-FAP ADCC Recombinant Antibody (Sibrotuzumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for ACFP-SH008. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare