Products

Anti-FCGR1 immunotoxin H22 (scFv)-RTA (AGTO-G024R)

This immunotoxin was achieved by conjugating/fusing the Anti-FCGR1A scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to acute myeloid leukemia (AML) cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute myeloid leukemia.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
H22
Molecule Class
scFv-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
acute myeloid leukemia
Target
Alternative Names
FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); CD64; FCRI; CD64A; IGFR1; high affinity immunoglobulin gamma Fc receptor I; fcgammaRIa
Entrez Gene ID
2209
UniProt ID
P12314

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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