Anti-Human FGFR1 Recombinant Antibody scFv Fragment (FR1-H7) (CAT#: TAB-052WM-S(P))
Antibody FR1-H7 binds FGFR-1(IIIb) and -1(IIIc) with strong affinities, but does not recognize any of the other FGFRs. Results from kinetic analysis indicated the antibody binds to FGFR-1b and -1c equally well. The KDs of the interactions were determined to be approximately 50 μM for both receptors. This product can be potentially used for antagonizing EGFR-1 or EGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_B_9_5.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_B_9_5.jpg
Figure 2 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_9_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_9_3.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_8_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_6_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (AN3-CA, BJ hTERT+)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077782-FGFR1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077782-FGFR1
Specifications
- Host Species
- Human
- Derivation
- Phage-displayed human Fab library
- Type
- Human Antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- FR1-H7
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Neutralization; Blocking
- Related Disease
- Obesity, diabetes
Target
- Alternative Names
- FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1
- Gene ID
- 2260
- UniProt ID
- P11362
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone FR1-H7"
See other products for "FGFR1"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-283CL | Human Anti-FGFR1 Recombinant Antibody (TAB-283CL) | WB, IHC | Human IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-052WM | Anti-Human FGFR1 Recombinant Antibody (FR1-H7) | ELISA, Neut | Human Antibody |
| TAB-054WM | Human Anti-FGFR1 Recombinant Antibody (TAB-054WM) | ELISA | Human IgG |
| TAB-054WM-S(P) | Human Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-054WM-S(P)) | ELISA | Human scFv |
| TAB-052WM-F(E) | Anti-Human FGFR1 Recombinant Antibody Fab Fragment (FR1-H7) | ELISA, BL, Neut | Human Antibody |
| TAB-054WM-F(E) | Human Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-054WM-F(E)) | ELISA | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-053WM | Mouse Anti-FGFR1 Recombinant Antibody (TAB-053WM) | WB, FC | Mouse IgG |
| TAB-053WM-S(P) | Mouse Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-053WM-S(P)) | WB | Mouse scFv |
| TAB-053WM-F(E) | Mouse Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-053WM-F(E)) | WB | Mouse Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0108MZ | Recombinant Mouse Anti-Human FGFR1 Antibody (clone N6G11) | WB, IP, IHC | Mouse antibody |
| HPAB-0489LY | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-C7) | ELISA | Human IgG |
| HPAB-0490LY | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-E1) | ELISA | Human IgG |
| HPAB-3044LY | Mouse Anti-FGFR1 Recombinant Antibody (HPAB-3044LY) | ELISA | Mouse IgG |
| VS3-CJ590 | Rabbit Anti-FGFR1 Recombinant Antibody (VS3-CJ590) | WB, ICC, IF | Rabbit IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-825CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone CBL537) | WB, Neut | Mouse IgG1 |
| NEUT-826CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone MM0277-6F10) | WB, Neut | Mouse IgG1 |
| NEUT-827CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone CBL059) | Neut, WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1296 | Hi-Affi™ Rabbit Anti-FGFR1 Recombinant Antibody (clone DS1296AB) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0118-FY-S(P) | Human Anti-FGFR1 Recombinant Antibody; scFv Fragment (HPAB-0118-FY-S(P)) | ELISA | Human scFv |
| HPAB-N0346-YC-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone SEEDbody A08); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-0485LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); scFv Fragment | ELISA | Human scFv |
| HPAB-0701-FY-F(E) | Mouse Anti-FGFR1 Recombinant Antibody (clone Ab21); scFv Fragment | ELISA | Mouse scFv |
| HPAB-3044LY-S(P) | Mouse Anti-FGFR1 Recombinant Antibody; scFv Fragment (HPAB-3044LY-S(P)) | ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0118-FY-F(E) | Human Anti-FGFR1 Recombinant Antibody; Fab Fragment (HPAB-0118-FY-F(E)) | ELISA | Human Fab |
| HPAB-0485LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); Fab Fragment | ELISA | Human Fab |
| HPAB-0486LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A9/H10); Fab Fragment | ELISA | Human Fab |
| HPAB-0487LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-B1/E12); Fab Fragment | ELISA | Human Fab |
| HPAB-0701-FY-S(P) | Mouse Anti-FGFR1 Recombinant Antibody (clone Ab21); Fab Fragment | ELISA | Mouse Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for TAB-052WM-S(P). Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.