Afuco™ Anti-Human FGFR2 ADCC Recombinant Antibody (BAY 1179470), ADCC Enhanced (CAT#: AFC-271CL)
Anti-FGFR2 ADCC Enhanced Antibody (BAY 1179470) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a novel fibroblast growth factor receptor 2 (FGFR2) directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
Figure 3 IHC staining of human skin
(Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
(Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
Figure 5 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, BEWO, CACO-2, HaCaT, HAP1, NTERA-2, T-47d)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
Specifications
- Host Species
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Store at -20°C. Open under aseptic conditions.
Target
- Alternative Names
- FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14
- Gene ID
- 2263
- UniProt ID
- P21802
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FGFR2"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1370z | Mouse Anti-FGFR2 Recombinant Antibody (clone 5F10) | ELISA, IHC, WB | Mouse IgG2b, κ |
| HPAB-0135-WJ | Human Anti-FGFR2 Recombinant Antibody (HPAB-0135-WJ) | ELISA, FC | Humanized IgG |
| HPAB-AP348-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-AP348-YC) | ELISA, FC, Neut, ADCC, FuncS | Chimeric (rat/human) IgG |
| HPAB-AP349-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-AP349-YC) | ELISA, FC, Neut, ADCC, FuncS | Chimeric (rat/human) IgG |
| HPAB-AP350-YC | Rat Anti-FGFR2 Recombinant Antibody (HPAB-AP350-YC) | ELISA, FC, Neut, ADCC, FuncS | Rat IgG |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B026(A) | Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B026(G) | Recombinant Anti-human FGFR2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B026(T) | Recombinant Anti-human FGFR2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-284CL | Anti-Human FGFR2 Recombinant Antibody (BAY 1179470) | IF, WB | Antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-055WM | Anti-Human FGFR2 Recombinant Antibody (GP369/4B9) | FC | |
| TAB-056WM | Mouse Anti-FGFR2 Recombinant Antibody (TAB-056WM) | IHC, ELISA, FC, Block | Mouse IgG1 |
| TAB-058WM | Rat Anti-FGFR2 Recombinant Antibody (TAB-058WM) | ELISA, FC, Inhib | Rat IgG2a, κ |
| TAB-059WM | Anti-Human FGFR2 Recombinant Antibody (Atto-MuMab-01) | ELISA, WB, FC | |
| TAB-055WM-F(E) | Anti-Human FGFR2 Recombinant Antibody Fab Fragment (GP369/4B9) | ELISA, FC |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-057WM | Human Anti-FGFR2 Recombinant Antibody (TAB-057WM) | ELISA, FC, Block | Human IgG1 |
| TAB-057WM-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-057WM-S(P)) | ELISA, FC, Block | Human scFv |
| TAB-057WM-F(E) | Human Anti-FGFR2 Recombinant Antibody; Fab Fragment (TAB-057WM-F(E)) | ELISA, FC, Block | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-060WM | Anti-Human FGFR2 Recombinant Antibody (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
| TAB-060WM-S(P) | Anti-Human FGFR2 Recombinant Antibody scFv Fragment (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
| TAB-061WM-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-061WM-S(P)) | Neut, WB, ELISA | Human scFv |
| TAB-060WM-F(E) | Anti-Human FGFR2 Recombinant Antibody Fab Fragment (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
| TAB-061WM-F(E) | Human Anti-FGFR2 Recombinant Antibody; Fab Fragment (TAB-061WM-F(E)) | Neut, WB, ELISA | Human Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-828CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL511) | WB, Neut | Mouse IgG1 |
| NEUT-829CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL512) | WB, FC, CyTOF®, Neut | Mouse IgG1 |
| NEUT-830CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL513) | FC, IHC, CyTOF®, Neut | Mouse IgG1 |
| NEUT-831CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone 6L19) | IHC, Neut, WB | Mouse IgG1 |
| NEUT-832CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL060) | Neut, WB, IHC | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1298 | Hi-Affi™ Rabbit Anti-FGFR2 Recombinant Antibody (clone DS1298AB) | WB, IP | Rabbit IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-027CN | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01) | ELISA, WB, FC | Human IgG1 |
| NS-027CN-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01); Fab Fragment | ELISA, WB, FC | Human Fab |
| NS-027CN-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01); scFv Fragment | ELISA, WB, FC | Human scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020-FY-S(P) | Mouse Anti-FGFR2 Recombinant Antibody; scFv Fragment (HPAB-0020-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0791-FY-F(E) | Mouse Anti-FGFR2 Recombinant Antibody; Fab Fragment (HPAB-0791-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0098-WJ-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone 15492.77); scFv Fragment | ELISA | Human scFv |
| HPAB-0135-WJ-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (HPAB-0135-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0361-YJ-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone CBF55YJ); scFv Fragment | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0674-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M047-D08); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0675-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M017-B02); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0676-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M021-H02); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0677-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M054-D03); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0678-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M054-A05); Fab Fragment | ELISA, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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