Recombinant Human monoclonal antibody expressed in CHO binding to Human FGFR2. This is a novel fibroblast growth factor receptor 2 (FGFR2) directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance.
Figure 1 The FGFR2-specific Ab (BAY 1179470) induces FGFR2 internalization and degradation in vitro.
Fluorescence immunocytochemistry was used to evaluate the FGFR2-Ab-induced internalization of FGFR2 in cells with high (SUM-52PE) FGFR2 expression.
Sommer, A., Kopitz, C., Schatz, C. A., Nising, C. F., Mahlert, C., Lerchen, H. G., ... & Braun, M. (2016). Preclinical efficacy of the auristatin-based antibody–drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors. Cancer research, 76(21), 6331-6339.
Figure 2 Antitumor efficacy of FGFR2-ADC in OV30-0511A ovarian cancer PDX model.
Immunoblot indicates a high level of FGFR2 protein expression in the OV30-0511A model.
Sommer, A., Kopitz, C., Schatz, C. A., Nising, C. F., Mahlert, C., Lerchen, H. G., ... & Braun, M. (2016). Preclinical efficacy of the auristatin-based antibody–drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors. Cancer research, 76(21), 6331-6339.
Figure 3 Localization of Cypher 5E-labeled FGFR2-Ab (red) 6 hours after incubation with live SUM-52PE cells and subsequent staining with anti-Rab7.
Yellow regions indicate colocalization. Blue DNA stain indicates the nucleus.
Sommer, A., Kopitz, C., Schatz, C. A., Nising, C. F., Mahlert, C., Lerchen, H. G., ... & Braun, M. (2016). Preclinical efficacy of the auristatin-based antibody–drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors. Cancer research, 76(21), 6331-6339.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B026(A) | Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
IAB-B026(G) | Recombinant Anti-human FGFR2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
IAB-B026(T) | Recombinant Anti-human FGFR2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-057WM | Human Anti-FGFR2 Recombinant Antibody (TAB-057WM) | ELISA, FC, Block | Human IgG1 |
TAB-057WM-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-057WM-S(P)) | ELISA, FC, Block | Human scFv |
TAB-057WM-F(E) | Human Anti-FGFR2 Recombinant Antibody; Fab Fragment (TAB-057WM-F(E)) | ELISA, FC, Block | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-060WM | Anti-Human FGFR2 Recombinant Antibody (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
TAB-061WM | Human Anti-FGFR2 Recombinant Antibody (TAB-061WM) | Neut, WB, ELISA | Human IgG |
TAB-060WM-S(P) | Anti-Human FGFR2 Recombinant Antibody scFv Fragment (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
TAB-061WM-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-061WM-S(P)) | Neut, WB, ELISA | Human scFv |
TAB-060WM-F(E) | Anti-Human FGFR2 Recombinant Antibody Fab Fragment (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-055WM-S(P) | Anti-Human FGFR2 Recombinant Antibody scFv Fragment (GP369/4B9) | ELISA, FC | |
TAB-055WM-F(E) | Anti-Human FGFR2 Recombinant Antibody Fab Fragment (GP369/4B9) | ELISA, FC | |
TAB-056WM-F(E) | Mouse Anti-FGFR2 Recombinant Antibody; Fab Fragment (TAB-056WM-F(E)) | ELISA, FC, Block | Mouse Fab |
TAB-058WM-F(E) | Rat Anti-FGFR2 Recombinant Antibody; Fab Fragment (TAB-058WM-F(E)) | ELISA, FC, Neut, Inhib | Rat Fab |
TAB-059WM-F(E) | Anti-Human FGFR2 Recombinant Antibody Fab Fragment (Atto-MuMab-01) | ELISA, WB, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0737CT | Recombinant Mouse anti-Human FGFR2 Monoclonal antibody (EML2262) | ICC/IF, IHC-P, WB | |
HPAB-0144-YC | Human Anti-FGFR2 Recombinant Antibody (clone Hu4B9-65) | FuncS | Humanized IgG1, κ |
HPAB-0146-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-0146-YC) | ELISA, FC, Neut | Chimeric (rat/human) IgG |
HPAB-0147-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-0147-YC) | ELISA, FC, Neut | Humanized IgG |
HPAB-0020-FY | Mouse Anti-FGFR2 Recombinant Antibody (HPAB-0020-FY) | ELISA | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-828CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL511) | WB, Neut | Mouse IgG1 |
NEUT-829CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL512) | WB, FC, CyTOF®, Neut | Mouse IgG1 |
NEUT-830CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL513) | FC, IHC, CyTOF®, Neut | Mouse IgG1 |
NEUT-831CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone 6L19) | IHC, Neut, WB | Mouse IgG1 |
NEUT-832CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL060) | Neut, WB, IHC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1298 | Hi-Affi™ Rabbit Anti-FGFR2 Recombinant Antibody (clone DS1298AB) | WB, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-027CN | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01) | ELISA, WB, FC | Human IgG1 |
NS-027CN-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01); Fab Fragment | ELISA, WB, FC | Human Fab |
NS-027CN-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01); scFv Fragment | ELISA, WB, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0020-FY-S(P) | Mouse Anti-FGFR2 Recombinant Antibody; scFv Fragment (HPAB-0020-FY-S(P)) | ELISA | Mouse scFv |
HPAB-0791-FY-F(E) | Mouse Anti-FGFR2 Recombinant Antibody; Fab Fragment (HPAB-0791-FY-F(E)) | ELISA | Mouse Fab |
HPAB-0674-WJ-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone M047-D08); scFv Fragment | ELISA, FC | Human scFv |
HPAB-0675-WJ-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone M017-B02); scFv Fragment | ELISA, FC | Human scFv |
HPAB-0676-WJ-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone M021-H02); scFv Fragment | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0791-FY-S(P) | Mouse Anti-FGFR2 Recombinant Antibody; scFv Fragment (HPAB-0791-FY-S(P)) | ELISA | Mouse scFv |
HPAB-AP348-YC-F(E) | Human Anti-FGFR2 Recombinant Antibody; Fab Fragment (HPAB-AP348-YC-F(E)) | ELISA, FC, Neut, ADCC, FuncS | Chimeric (rat/human) Fab |
HPAB-AP349-YC-F(E) | Human Anti-FGFR2 Recombinant Antibody; Fab Fragment (HPAB-AP349-YC-F(E)) | ELISA, FC, Neut, ADCC, FuncS | Chimeric (rat/human) Fab |
HPAB-AP350-YC-F(E) | Rat Anti-FGFR2 Recombinant Antibody; Fab Fragment (HPAB-AP350-YC-F(E)) | ELISA, FC, Neut, ADCC, FuncS | Rat Fab |
HPAB-0361-YJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone CBF55YJ); Fab Fragment | ELISA | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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