Anti-Human FGFR2 Recombinant Antibody (BAY 1179470) (CAT#: TAB-284CL)

Recombinant Human monoclonal antibody expressed in CHO binding to Human FGFR2. This is a novel fibroblast growth factor receptor 2 (FGFR2) directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
IF

Figure 1 The FGFR2-specific Ab (BAY 1179470) induces FGFR2 internalization and degradation in vitro.

Figure 1 The FGFR2-specific Ab (BAY 1179470) induces FGFR2 internalization and degradation in vitro.

Fluorescence immunocytochemistry was used to evaluate the FGFR2-Ab-induced internalization of FGFR2 in cells with high (SUM-52PE) FGFR2 expression.

Sommer, A., Kopitz, C., Schatz, C. A., Nising, C. F., Mahlert, C., Lerchen, H. G., ... & Braun, M. (2016). Preclinical efficacy of the auristatin-based antibody–drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors. Cancer research, 76(21), 6331-6339.

WB

Figure 2 Antitumor efficacy of FGFR2-ADC in OV30-0511A ovarian cancer PDX model.

Figure 2 Antitumor efficacy of FGFR2-ADC in OV30-0511A ovarian cancer PDX model.

Immunoblot indicates a high level of FGFR2 protein expression in the OV30-0511A model.

Sommer, A., Kopitz, C., Schatz, C. A., Nising, C. F., Mahlert, C., Lerchen, H. G., ... & Braun, M. (2016). Preclinical efficacy of the auristatin-based antibody–drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors. Cancer research, 76(21), 6331-6339.

IF

Figure 3 Localization of Cypher 5E-labeled FGFR2-Ab (red) 6 hours after incubation with live SUM-52PE cells and subsequent staining with anti-Rab7.

Figure 3 Localization of Cypher 5E-labeled FGFR2-Ab (red) 6 hours after incubation with live SUM-52PE cells and subsequent staining with anti-Rab7.

Yellow regions indicate colocalization. Blue DNA stain indicates the nucleus.

Sommer, A., Kopitz, C., Schatz, C. A., Nising, C. F., Mahlert, C., Lerchen, H. G., ... & Braun, M. (2016). Preclinical efficacy of the auristatin-based antibody–drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors. Cancer research, 76(21), 6331-6339.


Specifications

  • Host Species
  • Human
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Applications
  • IF, WB
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95%, by SDS-PAGE, under reducing conditions
  • Storage
  • Store at -20°C. Open under aseptic conditions.

Applications

  • Application Notes
  • This antibody has been reported for use in Western Blot and Immunofluorescence.

Target

  • Alternative Names
  • FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein;

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "FGFR2"

Intrabody

CAT Product Name Application Type
IAB-B026(A) Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] IF, FC, FuncS scFv-(D-Arg)9
IAB-B026(G) Recombinant Anti-human FGFR2 Intrabody [+36 GFP] WB, ICC, FuncS scFv-(+36GFP)
IAB-B026(T) Recombinant Anti-human FGFR2 Intrabody [Tat] ICC, Neut, FuncS scFv-Tat

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1298 Hi-Affi™ Rabbit Anti-FGFR2 Recombinant Antibody (clone DS1298AB) WB, IP Rabbit IgG

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-284CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare