Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] (CAT#: IAB-B029(A))

Recombinant anti-FOLR1 intrabody linked to (D-Arg)9 works within cells to bind FOLR1, which is selectively overexpressed in 90% of nonmucinous ovarian carcinomas, expressed in CHO cells. FR expression is associated with tumor progression and affects cell proliferation and the intracellular expression of single-chain (sc) antibodiess (intrabody) can downmodulate membrane expression of FR in ovary cancer cells.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
RNA Expression

Specifications

  • Immunogen
  • human folate receptor 1 (adult)
  • Host Species
  • mouse
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Can be useful in applications such as: Protein fragment complementation; Neutralization; Functional studies

Product Property

  • Purity
  • >98% by SDS-PAGE and HPLC analysis
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Target

  • Alternative Names
  • FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "FOLR1"

Intrabody

CAT Product Name Application Type
IAB-B029(G) Recombinant Anti-human FOLR1 Intrabody [+36 GFP] WB, Neut, FuncS scFv-(+36GFP)
IAB-B029(T) Recombinant Anti-human FOLR1 Intrabody [Tat] WB, ICC, Neut, FuncS scFv-Tat

Humanized Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-018CQ Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) ELISA, WB, IHC Chimeric (Rat/Human) IgG1, κ
TAB-018CQ-S(P) Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) ELISA, WB, IHC Human scFv
TAB-018CQ-F(E) Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) ELISA, WB, IHC Chimeric (Rat/Human) Fab

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-029LC-1 Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1333 Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-113 Afuco™ Anti-FOLR1 ADCC Recombinant Antibody (Farletuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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