Recombinant Anti-human FOLR1 Intrabody [Tat] (CAT#: IAB-B029(T))

Recombinant anti-FOLR1 intrabody in fusion with HIV Tat works within cells to bind FOLR1, which is selectively overexpressed in 90% of nonmucinous ovarian carcinomas, expressed in CHO cells. FR expression is associated with tumor progression and affects cell proliferation and the intracellular expression of single-chain (sc) antibodiess (intrabody) can downmodulate membrane expression of FR in ovary cancer cells.


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
RNA Expression

Specifications

  • Immunogen
  • human folate receptor 1 (adult)
  • Host Species
  • mouse
  • Type
  • scFv-Tat
  • Cell Penetrating Peptide
  • TAT
    TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
  • Species Reactivity
  • human
  • Applications
  • Antibody assay: Western blot; Immunocytochemistry; Neutralization; Functional studies

Product Property

  • Purity
  • >95% as judged by SDS-polyacrylamide gel electrophoresis
  • Storage
  • 4°C or -20°C, avoid repeated freezing and thawing.

Target

  • Alternative Names
  • FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "FOLR1"

Intrabody

CAT Product Name Application Type
IAB-B029(A) Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] PCA, Neut, FuncS scFv-(D-Arg)9
IAB-B029(G) Recombinant Anti-human FOLR1 Intrabody [+36 GFP] WB, Neut, FuncS scFv-(+36GFP)

Humanized Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-018CQ Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) ELISA, WB, IHC Chimeric (Rat/Human) IgG1, κ
TAB-018CQ-S(P) Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) ELISA, WB, IHC Human scFv
TAB-018CQ-F(E) Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) ELISA, WB, IHC Chimeric (Rat/Human) Fab

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-029LC-1 Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1333 Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-113 Afuco™ Anti-FOLR1 ADCC Recombinant Antibody (Farletuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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