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Anti-G3BP1 Intrabody [(D-Arg)9] (IAB-B011(A))

Recombinant anti-G3BP1 intrabody linked to (D-Arg)9 works within cells to bind human G3BP1, expressed in 293T cells.      

Specifications
Immunogen
human GTPase activating protein (SH3 domain) binding protein 1
Host
human
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Antibody assay: Protein fragment complementation; Neutralization; Functional studies
Target
Alternative Names
G3BP1; GTPase activating protein (SH3 domain) binding protein 1; G3BP; HDH-VIII; ras GTPase-activating protein-binding protein 1; G3BP-1; GAP binding protein; ATP-dependent DNA helicase VIII
Entrez Gene ID
10146
UniProt ID
Q13283

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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