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Anti-GCC (5F9)-mc-val-cit-PABC-MMAE ADC (MLN0264) (CAT#: ADC-L035)

This ADC product is composed of an anti-GCC antibody (clone 5F9) conjuagated via a mc-val-cit-PABC linker to MMAE (5F9-mc-val-cit-PABC-MMAE). It has demonstrated a response in advanced gastrointestinal malignancies treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73759/1520_C2_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/ihc_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_B_9_5.jpg
Figure 4 Oral mucosa
Figure 4 Oral mucosa
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_1.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_3.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_4_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37655/78314_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, CACO-2, CAPAN-2, SiHa)
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, CACO-2, CAPAN-2, SiHa)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070019-GUCY2C

Specifications

  • Antibody Overview
  • Fully human IgG1k monoclonal antibody that binds to GCC
  • Clone
  • 5F9
  • Antibody Conjugation
  • Human
  • Linker
  • mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl )
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin
  • Alternative Names
  • STAR; DIAR6; GUC2C; MECIL; MUCIL

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Recombinant Antibody

CAT Product Name Application Type
MOB-2397z Mouse Anti-GUCY2C Recombinant Antibody (MOB-2397z) ELISA, WB Mouse IgG2b, κ
MOB-069CQ Mouse Anti-GUCY2C Recombinant Antibody (clone YC099) WB, IP, ELISA Mouse IgG2b, κ
HPAB-AP097-YC Rabbit Anti-GUCY2C Recombinant Antibody (HPAB-AP097-YC) ELISA, IHC Rabbit IgG
VS4-WK208 Human Anti-GUCY2C Recombinant Antibody (clone 2E5) ELISA, FC Human IgG
VS4-WK209 Mouse Anti-GUCY2C Recombinant Antibody (clone 4G12) ELISA, FC Mouse IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-2397z-F(E) Recombinant Anti-Human GUCY2C Antibody Fab Fragment Neut, IF, FuncS Fab
HPAB-AP097-YC-F(E) Rabbit Anti-GUCY2C Recombinant Antibody; Fab Fragment (HPAB-AP097-YC-F(E)) ELISA, IHC Rabbit Fab
HPAB-AP098-YC-F(E) Rabbit Anti-GUCY2C Recombinant Antibody; Fab Fragment (HPAB-AP098-YC-F(E)) ELISA, IHC Rabbit Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-2397z-S(P) Recombinant Anti-Human GUCY2C Antibody scFv Fragment IF, FC, Biosensors, FuncS scFv
HPAB-AP097-YC-S(P) Rabbit Anti-GUCY2C Recombinant Antibody; scFv Fragment (HPAB-AP097-YC-S(P)) ELISA, IHC Rabbit scFv
HPAB-AP098-YC-S(P) Rabbit Anti-GUCY2C Recombinant Antibody; scFv Fragment (HPAB-AP098-YC-S(P)) ELISA, IHC Rabbit scFv

Mouse Antibody

CAT Product Name Application Type
TAB-061CQ Mouse Anti-GUCY2C Recombinant Antibody (TAB-061CQ) ELISA, FC, IF Mouse IgG1, κ
TAB-061CQ-S(P) Mouse Anti-GUCY2C Recombinant Antibody; scFv Fragment (TAB-061CQ-S(P)) ELISA, FC, WB Mouse scFv
TAB-062CQ-S(P) Mouse Anti-GUCY2C Recombinant Antibody; scFv Fragment (TAB-062CQ-S(P)) ELISA, FC, WB Mouse scFv
TAB-061CQ-F(E) Mouse Anti-GUCY2C Recombinant Antibody; Fab Fragment (TAB-061CQ-F(E)) ELISA, FC, WB Mouse Fab
TAB-062CQ-F(E) Human Anti-GUCY2C Recombinant Antibody; Fab Fragment (TAB-062CQ-F(E)) ELISA, FC, WB Chimeric (mouse/human) Fab

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0245MZ Chicken Anti-GUCY2C Polyclonal IgY WB Chicken antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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