Recombinant Human Antibody (mAb1) is capable of binding to GCGR, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-GCGR mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-GCGR proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The mechanisms of glucagon receptor inhibition by blocking antibodies targeting the receptor's extracellular domain (ECD).
Figure 1 Western blot analysis of stable 293 cells expressing WT or G40S GCGR, probed with anti-GCGR mAb1.
WT or G40S -ve refers to cells incubated without anti-GCGR.
Mukund, S., Shang, Y., Clarke, H. J., Madjidi, A., Corn, J. E., Kates, L., ... & Zhang, Y. (2013). Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor. Journal of Biological Chemistry, 288(50), 36168-36178.
Figure 2 FACS analysis of stable 293 cells expressing WT or G40S GCGR using anti-GCGR mAb1.
WT or G40S -ve refers to cells incubated without anti-GCGR.
Mukund, S., Shang, Y., Clarke, H. J., Madjidi, A., Corn, J. E., Kates, L., ... & Zhang, Y. (2013). Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor. Journal of Biological Chemistry, 288(50), 36168-36178.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1786z | Mouse Anti-GCGR Recombinant Antibody (clone 40C5) | WB, ELISA | Mouse IgG1, κ |
PABW-048 | Mouse Anti-GCGR Recombinant Antibody (clone HGR-2 F6) | Block | Mouse IgG |
HPAB-0023-LS | Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3) | WB, FC, FuncS | Mouse IgG1 κ |
HPAB-0138-FY | Human Anti-GCGR Recombinant Antibody (HPAB-0138-FY) | Block | Human IgG4, κ |
HPAB-3045LY | Human Anti-GCGR Recombinant Antibody (HPAB-3045LY) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-214 | Human Anti-GCGR Recombinant Antibody (clone mAb1); Fab Fragment | Neut, WB | Human Fab |
PSBW-048 | Mouse Anti-GCGR Recombinant Antibody (clone HGR-2 F6); scFv Fragment | Block | Mouse scFv |
HPAB-0023-LS-F(E) | Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3); Fab Fragment | WB, FC | Mouse Fab |
HPAB-0138-FY-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0138-FY-S(P)) | Block | Human scFv |
HPAB-0105LY-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0105LY-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-063CQ | Anti-Human GCGR Recombinant Antibody (mAb5) | ELISA, FC | |
TAB-064CQ | Anti-Human GCGR Recombinant Antibody (3C7) | ELISA, FC, WB | |
TAB-067CQ | Mouse Anti-GCGR Recombinant Antibody (TAB-067CQ) | ELISA, FC | Mouse IgG |
TAB-063CQ-S(P) | Anti-Human GCGR Recombinant Antibody scFv Fragment (mAb5) | ELISA, FC | |
PABX-067-F (E) | Recombinant Mouse Anti-GR-2 Antibody Fab Fragment (F6) | WB, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-066CQ | Anti-Human GCGR Recombinant Antibody (3C7v11) | ELISA, FC, WB | Humanized antibody |
TAB-066CQ-S(P) | Anti-Human GCGR Recombinant Antibody scFv Fragment (3C7v11) | ELISA, FC, WB | Humanized antibody |
TAB-066CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (3C7v11) | ELISA, FC, WB | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-068CQ-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (TAB-068CQ-S(P)) | ELISA, FC | Human scFv |
TAB-069CQ-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (TAB-069CQ-S(P)) | ELISA, FC | Human scFv |
TAB-065CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (H6.23v3) | ELISA, FC, WB | Human antibody |
TAB-068CQ-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (TAB-068CQ-F(E)) | ELISA, FC | Human Fab |
TAB-069CQ-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (TAB-069CQ-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-113LC | Recombinant Anti-Human GCGR Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0138-FY-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (HPAB-0138-FY-F(E)) | Block | Human Fab |
HPAB-0817-FY-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0817-FY-S(P)) | ELISA, RIA, FC | Human scFv |
HPAB-0818-FY-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0818-FY-S(P)) | ELISA, RIA, FC | Human scFv |
HPAB-0819-FY-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0819-FY-S(P)) | ELISA, RIA, FC | Human scFv |
HPAB-0820-FY-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (HPAB-0820-FY-S(P)) | ELISA, RIA, FC | Human scFv |
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