Products

Anti-GD2 Immunocytokine, IgG-ala (14.18)-IL12 (ACFP-SH141)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG-ala to IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of IL12. This immunocytokine was designed for treating neuroblastomas, medulloblastomas, astrocytomas, melanomas, small-cell lung cancer, osteosarcomas and other soft tissue sarcomas..      

Specifications
Target
GD2
Molecule Class
IgG2-ala-IL12
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
14.18
Related Disease
Neuroblastomas, Medulloblastomas, Astrocytomas, Melanomas, Small-cell lung cancer, Osteosarcomas and other soft tissue sarcomas.
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
Disialoganglioside GD2; Ganglioside G2; GD2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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