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Anti-GD2 Immunocytokine, IgG (ch14.18)-LT (ACFP-SH020)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG via its amino terminal amino acid to carboxy-terminus of LT. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of LT. This immunocytokine was designed for treating GD2-positive tumors.      

Specifications
Target
GD2
Molecule Class
L Kappa; IgG1-LT
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
ch14.18
Related Disease
GD2-positive tumors
Cytokines 1
LT
Cytokines 1 Description
Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. It is also known to be required for normal development of Peyer's patches. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
Disialoganglioside GD2; Ganglioside G2; GD2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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