Products

Anti-GD2 Immunocytokine, IgG (hu14.18)-IL2 (ACFP-SH046)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the IL2 to the H chain of anti-GD2 IgG but with a linker modification increasing half-life compared to hu14.18-IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of IL2. This immunocytokine was designed for treating neuroblastomas, medulloblastomas, astrocytomas, melanomas, small-cell lung cancer, osteosarcomas and other soft tissue sarcomas.      

Specifications
Target
GD2
Molecule Class
L Kappa; IgG1-IL2
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
hu14.18
Related Disease
Neuroblastomas, Medulloblastomas, astrocytomas, Melanomas, Small-cell lung cancer, Osteosarcomas and other soft tissue sarcomas.
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
Disialoganglioside GD2; Ganglioside G2; GD2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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