Anti-Human GHR Recombinant Antibody (GF185) (CAT#: TAB-262CQ)

Recombinant monoclonal antibody to GHR. This antibody binds to epitopes that are localized within subdomain 1 of GHR-ECD and is able to neutralize growth hormone (GH) signalling and inhibit GH-induced Ba/F3-GHR proliferation.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FC

Figure 1 Flow cytometric screening of potential anti-GHBP monoclonal antibodies that can bind to CHO-GHR.

Figure 1 Flow cytometric screening of potential anti-GHBP monoclonal antibodies that can bind to CHO-GHR.

Cui, H., Wang, Y., Song, M., & Zhang, H. (2016). Preparation and Characterization of an Antibody Antagonist That Targets the Porcine Growth Hormone Receptor. Asian-Australasian journal of animal sciences,  29(10), 1508.

IP

Figure 2 GF185 was determined to interact with full-length GHR expressed on CHO-GHR cells by immunoprecipitation experiments.

Figure 2 GF185 was determined to interact with full-length GHR expressed on CHO-GHR cells by immunoprecipitation experiments.

Cui, H., Wang, Y., Song, M., & Zhang, H. (2016). Preparation and Characterization of an Antibody Antagonist That Targets the Porcine Growth Hormone Receptor. Asian-Australasian journal of animal sciences,  29(10), 1508.

Inhib

Figure 3 Inhibition of GH-induced proliferation of Ba/F3-GHR by GF185.

Figure 3 Inhibition of GH-induced proliferation of Ba/F3-GHR by GF185.

Cui, H., Wang, Y., Song, M., & Zhang, H. (2016). Preparation and Characterization of an Antibody Antagonist That Targets the Porcine Growth Hormone Receptor. Asian-Australasian journal of animal sciences,  29(10), 1508.


Specifications

  • Immunogen
  • GHBP
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • GF185
  • Applications
  • FC, IP, Inhib
  • Related Disease
  • GH-dependent disease

Applications

  • Application Notes
  • This antibody has been tested for use in Flow Cytometry, Immunoprecipitation, Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • GHR; growth hormone receptor; GHBP; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone GF185"

See other products for "GHR"

Single-domain Antibody

CAT Product Name Application Type
NAB-1090-VHH Recombinant Anti-Human GHR VHH Single Domain Antibody FA, FC, ICC, ELISA Llama VHH

Humanized Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1438 Hi-Affi™ Rabbit Anti-GHR Recombinant Antibody (clone DS1438AB) WB, ICC, FC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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