Products

Anti-GLI3 Intrabody [(D-Arg)9] (IAB-B069(A))

Recombinant anti-GLI3 intrabody linked to (D-Arg)9 works within cells to bind specific to the repressor domain of human GLI3, expressed in E. coli cells. Such a scFv constitutes a useful tool for studying transcriptional regulation of the hedgehog pathway in mammals and offers a starting point for developing novel Gli-related therapeutic intrabodies.      

Specifications
Immunogen
human GLI family zinc finger 3
Host
llama
Type
vhh-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Formats of immunological tests: Immunofluorescence; Flow Cytometry; Western blot; Functional studies
Target
Alternative Names
GLI3; GLI family zinc finger 3; PHS; ACLS; GCPS; PAPA; PAPB; PAP-A
Entrez Gene ID
2737
UniProt ID
P10071

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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