Anti-Human Gb3 Recombinant Antibody (3E2) (CAT#: TAB-050CQ)

The antibody which directs against the membrane glycosphingolipid globotriaosylceramide (Gb3) can be potentially used for staining cells expressing Gb3 and has an antiangiogenic activity on proliferating endothelial cells. The antibody may be used in the treatment of diseases associated with angiogenesis, and particularly solid tumors.


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FC

Figure 1 Gb3-positive HMEC-1 cells determined by Facs 24 h after treatment (n = 3).

Figure 1 Gb3-positive HMEC-1 cells determined by Facs 24 h after treatment (n = 3).

Desselle, A., Chaumette, T., Gaugler, M. H., Cochonneau, D., Fleurence, J., Dubois, N., ... & Paris, F. (2012). Anti-Gb3 monoclonal antibody inhibits angiogenesis and tumor development. PLoS One,  7(11), e45423.

ELISA

Figure 2 Vascular density estimated on 50 different slides on 3 different treated tumors (mean6SEM; *p, 0.01; n = 3).

Figure 2 Vascular density estimated on 50 different slides on 3 different treated tumors (mean6SEM; *p, 0.01; n = 3).

Desselle, A., Chaumette, T., Gaugler, M. H., Cochonneau, D., Fleurence, J., Dubois, N., ... & Paris, F. (2012). Anti-Gb3 monoclonal antibody inhibits angiogenesis and tumor development. PLoS One,  7(11), e45423.


Specifications

  • Immunogen
  • Neutral glycolipid Gb3
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • 3E2
  • Applications
  • ELISA, FC
  • Related Disease
  • Solid Tumors

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA, Flow Cytometry. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • Gb3; Glycosphingolipid globotriaosylceramide; CD77

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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