Recombinant Human Antibody (2G1) is capable of binding to H2N2 HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-H2N2 HA mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-H2N2 HA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. MAbs 8F8, 8M2, and 2G1, that were generated with hybridoma technology from the peripheral blood of middle-aged donors. These three antibodies showed a similar spectrum.
Figure 1 Microneutralization data of H2/H3-specific human MAbs
Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Albrecht, R., Blum, D., ... & Basler, C. F. (2012). Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses. Journal of virology, JVI-07158.
Figure 2 Therapeutic efficacy of MAbs against disease caused by the A/Albany/6/1958 H2N2 virus in mice.
Mice were inoculated on day 0 and treated on day 1 with the indicated antibody (8F8, 8M2, 2G1, or a human IgG control) and dose. In each group, six mice were monitored for survival (A) and weight (B). At the 8F8 200-μg dose (P < 0.01), the 8F8 20-μg dose (P < 0.05), the 8M2 200-μg dose (P < 0.01), the 2G1 200-μg dose (P < 0.01), and the 2G1 20-μg dose (P < 0.01), treatment conferred a survival advantage by log rank test.
Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Albrecht, R., Blum, D., ... & Basler, C. F. (2012). Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses. Journal of virology, JVI-07158.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-203 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (3.1) | WB, ELISA, FuncS | Fab |
PFBL-204 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (39.29) | Neut, FuncS | Fab |
PFBL-205 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1957) | WB, Neut, FuncS | Fab |
PFBL-206 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PFBL-207 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (5J8) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-480 | Recombinant Human Anti-H1N1 HA Antibody scFv Fragment (CH67) | Neut | scFv |
HPAB-N0122-YC-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (AF4H1K1) | IF, Neut, FuncS | Mouse scFv |
HPAB-N0123-YC-S(P) | Recombinant Humanized Anti-HA Antibody scFv Fragment (809) | Neut, ELISA | Humanized scFv |
HPAB-N0124-YC-S(P) | Recombinant Human Anti-HA Antibody scFv Fragment (mAb6137) | ELISA, Inhib, FuncS | Human scFv |
HPAB-N0125-YC-S(P) | Recombinant Human Anti-HA Antibody scFv Fragment (S9-1-10/5-1) | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABC-160 | Human Anti-HA Recombinant Antibody (PABC-160) | Neut, ELISA, FC | Human IgG |
FAMAB-0149YC | Recombinant Human Anti-HA Antibody (F005-126) | ELISA, FC, Neut | Human IgG |
FAMAB-0150YC | Recombinant Human Anti-HA Antibody (F026-427) | FC, Neut | Human IgG |
FAMAB-0151YC | Recombinant Human Anti-HA Antibody (F045-092) | FC, Neut | Human IgG |
HPAB-0928WJ | Recombinant Mouse Anti-HA Antibody (3C8) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-262CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D3-4) | WB, FC, IP | Human antibody |
MRO-263CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D4-2) | WB, FC, IP | Human antibody |
MRO-264CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D4-3) | WB, FC, IP | Human antibody |
MRO-265CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D4-4) | WB, FC, IP | Human antibody |
MRO-266CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D4-5) | WB, FC, IP | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-285CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (Clone 11) | WB, ELISA | |
MRO-286CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (Clone 2) | WB, ELISA | |
PABX-068-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PABX-069-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (S139/1 ) | ELISA, Neut, FuncS | Fab |
PABX-070-F (E) | Recombinant Mouse Anti-HA1 Antibody Fab Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-070-S (P) | Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4209 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI287DS) | ELISA, ICC/IF, IF, FC | IgG |
MOR-4210 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI288DS) | ELISA, ICC/IF, IF, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1169-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1169-FY) | Neut | Llama VHH |
HPAB-1170-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1170-FY) | Neut | Llama VHH |
HPAB-1171-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1171-FY) | Neut | Llama VHH |
HPAB-1172-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1172-FY) | Neut | Llama VHH |
HPAB-1173-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1173-FY) | Neut | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF182 | DRB1*01:01/Influenza HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF183 | DRB1*04:01/Influenza HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF890 | DRB1*04:02/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM | |
MHC-YF891 | DRB1*07:01/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM | |
MHC-YF1042 | APC-DRB1*04:02/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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