Anti-HCV E2 Recombinant Antibody (e137) (CAT#: MRO-1203LC)
This product is a recombinant human anti-Hepatitis C virus monoclonal antibody (e137). e137 and e8 were defined as recognizing two distinct epitopes on HCV/E2 and these epitopes were defined as nonneutralizing. e137 specifically binds to glycoprotein E2 associated with HCV and can be potentially used in the treatment and diagnosis of Hepatitis C virus infection.
Specific Inquiry
Neut
Figure 1 Critical residues abrogating mAb binding.
Antibodies are divided into neutralizers and non-neutralizers. Epitope residues are marked in red, while residues that are part of the CD81bs are underlined. The threshold below which a decrease in reactivity defines a residue as part of an epitope was determined for each antibody (e137 < 15%, e20 < 20%, e301 < 20%, e509 < 15%, e10 < 30%, e8 < 20%, H60 < 15%).
A Biologically-validated HCV E1E2 Heterodimer Structural Model
Neut
Figure 2 Inhibition of binding of probe FLAG-Fab antigen by previous binding of different concentrations of purified unlabeled Fabs used as competitors.
Mapping B-Cell Epitopes of Hepatitis C Virus E2 Glycoprotein Using Human Monoclonal Antibodies from Phage Display Libraries
Neut
Figure 3 Inhibition of binding of human recombinant Fabs by previous binding of a 1:20 dilution of sera obtained from HCV-infected patients and from two HCV-negative controls.
All HCV-positive sera were demonstrated to contain HCV RNA of genotype 1b and to have an ELISA titer against HCV/E2 of>1:500.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Hepatitis C virus
- Clone
- e137
- Applications
- ELISA, Neut
- Related Disease
- Hepatitis C virus infection
Applications
- Application Notes
- The HCV E2 Protein antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization.
Target
- Alternative Names
- Hepatitis C virus; HCV; HCV E2; Hepatitis C virus E2
- Gene ID
- 951475
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone e137"
See other products for "HCV E2 protein"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-446-S(P) | Recombinant Anti-HCV E2 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| PSBC-319 | Recombinant Mouse Anti-HCV E2 Antibody scFv Fragment (DAO5) | ELISA, FC | Mouse scFv |
| PSBC-415 | Human Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (PSBC-415) | ELISA, FC, Neut | Human scFv |
| FAMAB-0198JF-S(P) | Human Anti-HCV E2 Recombinant Antibody (clone L1); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0358JF-S(P) | Human Anti-HCV E2 Recombinant Antibody (clone 9e1); scFv Fragment | ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-446-F(E) | Recombinant Human Anti-HCV E2 Antibody Fab Fragment | WB, IHC, FuncS | Fab |
| PFBL-492 | Mouse Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (PFBL-492) | ELISA, Neut | Mouse Fab |
| PFBL-493 | Recombinant Mouse Anti-HCV E2 Antibody Fab Fragment (AP33) | ELISA | Fab |
| PFBL-494 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (AR3C) | Neut | Fab |
| PFBL-495 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (C2) | Neut | Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-476LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-476LC) | ELISA, Inhib | Chimeric (mouse/human) IgG |
| MRO-476LC-S(P) | Mouse Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-476LC-S(P)) | ELISA | Mouse scFv |
| MRO-476LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-476LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-477LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-477LC) | ELISA | Humanized IgG1, κ |
| MRO-478LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-478LC) | ELISA | Humanized IgG1, κ |
| MRO-479LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-479LC) | ELISA | Humanized IgG1, κ |
| MRO-477LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-477LC-F(E)) | ELISA | Humanized Fab |
| MRO-478LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-478LC-F(E)) | ELISA | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-485LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (AB 68) | ELISA | Human antibody |
| MRO-488LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (CBH-4D) | ELISA, WB | Human antibody |
| MRO-489LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (CBH-4B) | ELISA, WB | Human antibody |
| MRO-490LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (CBH-4G) | ELISA, WB | Human antibody |
| MRO-491LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (CBH-5) | ELISA, WB | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1191LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (A10F2) | ELISA | Mouse Antibody |
| MRO-1192LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (H6D3) | ELISA | Mouse Antibody |
| MRO-1193LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (E3D8) | ELISA | Mouse Antibody |
| MRO-1194LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (A7A6H9) | ELISA | Mouse Antibody |
| MRO-1195LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (G9E1) | ELISA | Mouse Antibody |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC428 | PE-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM | |
| MHC-LC429 | APC-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0065LC | Recombinant Mouse Anti-HCV E2 protein Antibody (JS-81) | ELISA | IgG1 |
| EPAF-1294LC | Recombinant Human Anti-HCV E2 protein Antibody (4c2) | ELISA |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0050-WJ | Mouse Anti-HCV E2 Protein Recombinant Antibody (HPAB-0050-WJ) | ELISA | Mouse IgG |
| PABC-474 | Recombinant Human Anti-HCV E2 Antibody (HCV1-C1) | ELISA, Neut | Human IgG1, κ |
| PABC-475 | Recombinant Mouse Anti-HCV E2 Antibody (MAb24) | FuncS, ELISA, Neut, IP | Mouse IgG1, κ |
| HPAB-0234-FY | Recombinant Human Anti-HCV E2 Antibody (TRN1008) | E, N | Human IgG |
| HPAB-0156-YJ | Recombinant Human Anti-HCV E2 Protein Antibody (e2d066) | ELISA, Inhib | Human IgG1, κ |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for MRO-1203LC. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.