Products

Anti-HER-2/neu Immunocytokine, scFv (scFv23)-TNFα (ACFP-SH060)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HER-2/neu scFv to TNFα. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HER-2/neu as well as the biological activity of TNFα. ScFv23/TNF is effective against cancers that are highly resistant to chemotherapy and that over-express HER-2/neu, for example, such as pancreatic tumors and breast tumors. ScFv23/TNF targeting the HER-2/neu may be an effective cytotoxic agent against HER-2/neu-overexpressing cancer cells, which are inherently resistant to TNF. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.      

Specifications
Target
HER-2/neu
Molecule Class
scFv-TNFα
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
scFv23
Related Disease
HER-2/neu over-expressing cancer
Cytokines 1
TNFα
Cytokines 1 Description
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, Psoriasis and inflammatory bowel disease (IBD). While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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