Products

Anti-HER2/neu Immunocytokine, IL12-IgG (trastuzumab)-GM-CSF (ACFP-SH189)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HER2/neu IgG to IL12 and GM-CSF. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the HER2/neu as well as the biological activity of IL12 and GM-CSF. The goal of this antibody-cytokine fusion protein to cancer therapy is to concentrate the cytokine in the tumor microenvironment and in so doing directly enhance the tumoricidal effect of the antibody and/or enhance the host immune response (T-cell, B-cell or NK) against the tumor. This Immunocytokines was designed for treating HER-2/neu over-expressing cancer.      

Specifications
Target
HER2/neu
Molecule Class
L kappa; IL12-IgG1-GM-CSF
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
trastuzumab
Related Disease
HER-2/neu over-expressing cancer
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Human
Cytokines 2
GM-CSF
Cytokines 2 Description
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
Cytokine 2 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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