Products

Anti-HER2/neu Immunocytokine, IL15-L22-IgG (trastuzumab) (ACFP-SH172)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HER2/neu IgG to IL15 and L22. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the HER2/neu as well as the biological activity of IL15 and L22. The goal of this antibody-cytokine fusion protein to cancer therapy is to concentrate the cytokine in the tumor microenvironment and in so doing directly enhance the tumoricidal effect of the antibody and/or enhance the host immune response (T-cell, B-cell or NK) against the tumor. This Immunocytokines was designed for treating HER-2/neu over-expressing cancer.      

Specifications
Target
HER2/neu
Molecule Class
L kappa; IL15-L22-IgG1
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
trastuzumab
Related Disease
HER-2/neu over-expressing cancer
Cytokines 1
IL15
Cytokines 1 Description
Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus (es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
Cytokine 1 Species
Human
Cytokines 2
L22
Cytokine 2 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved