Products

Anti-HER2/neu Immunocytokine, IgG (trastuzumab)-GM-CSF (ACFP-SH063)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HER2/neu IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HER2/neu as well as the biological activity of GM-CSF. In addition, the anti-HER2/neu IgG3-(GM-CSF) protein was capable of activating J774.2 murine macrophage cells enhancing their direct cytotoxic activity and also enhancing antibody-dependent macrophage-mediated tumor cell lysis. The anti-HER2/neu IgG3-(GM-CSF) fusion protein will be useful in the treatment of human HER2/neu-expressing tumors. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.      

Specifications
Target
HER2/neu
Molecule Class
L Kappa; IgG1-GM-CSF
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
trastuzumab
Related Disease
HER-2/neu over-expressing cancer
Cytokines 1
GM-CSF
Cytokines 1 Description
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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