Anti-Human HER3 Recombinant Antibody (SGP1) (CAT#: TAB-071CT)
This is a recombinant monoclonal antibody SGP1 to HER3. This antibody intended for the prophylaxis and treatment studies of Breast cancer, pancreatic cancer, lung cancer, gastric cancer.
Specific Inquiry
IF
Figure 1 SGP1 competes with Neuregulin 1 beta for binding to the HER3 receptor.
The breast cancer cell line MDA-MB-453 was labelled with (a). SGP1 detected with rabbit with antimouse Alexa Fluor 568, (b). SGP1 competed with 50nM Neuregulin 1 beta, (c). DAPI image of panel 1, (d). DAPI image of panel 2.
Blackburn, E., Zona, S., Murphy, M. L., Brown, I. R., Chan, S. K., & Gullick, W. J. (2012). A monoclonal antibody to the human HER3 receptor inhibits Neuregulin 1-beta binding and co-operates with Herceptin in inhibiting the growth of breast cancer derived cell lines. Breast cancer research and treatment, 134(1), 53-59.
Inhib
Figure 2 SGP1 inhibits growth stimulation by Neuregulin 1-beta.
MDA-MB-453 cells were incubated with 1nM Neuregulin 1-beta alone or in the presence of increasing concentrations of the SGP1 monoclonal antibody. (**P = < 0.01)
Blackburn, E., Zona, S., Murphy, M. L., Brown, I. R., Chan, S. K., & Gullick, W. J. (2012). A monoclonal antibody to the human HER3 receptor inhibits Neuregulin 1-beta binding and co-operates with Herceptin in inhibiting the growth of breast cancer derived cell lines. Breast cancer research and treatment, 134(1), 53-59.
Specifications
- Host Species
- Mouse
- Derivation
- Hybridoma cell line
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- SGP1
- Applications
- IF, Inhibition, FC
- Related Disease
- Breast cancer, pancreatic cancer, lung cancer, gastric cancer
Applications
- Application Notes
- The HER3 antibody has been reported in applications of Immunofluorescence, Inhibitionition, Flow Cytometry.
Target
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; LJM716
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (BCD090-M2) | ELISA, SPR | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H21 | Anti-Human ERBB3 Recombinant Antibody (Duligotuzumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | Human IgG |
| TAB-0033CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0033CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0034CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0034CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0035CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0035CL) | ELISA, FuncS, Inhib, FC | Human IgG |
| TAB-0036CL | Human Anti-ERBB3 Recombinant Antibody (TAB-0036CL) | ELISA, FuncS, Inhib, FC | Human IgG |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-086 | Human Anti-ERBB3 Recombinant Antibody (clone KTN3379) | ELISA, WB, IF, FuncS | Human IgG |
| PABL-127 | Human Anti-ERBB3 Recombinant Antibody (PABL-127) | ELISA, WB, FuncS | Human IgG |
| PABL-128 | Mouse Anti-ERBB3 Recombinant Antibody (PABL-128) | WB, Block, FuncS | Mouse IgG |
| HPAB-0022-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0022-WJ) | ELISA, Inhib, WB, FuncS | Human IgG1, λ |
| HPAB-0024-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0024-WJ) | ELISA | Human IgG1 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0508CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (1A5) | ELISA, Inhib, FuncS | |
| TAB-0509CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (3D4) | ELISA, Inhib, FuncS | |
| TAB-060CT | Rabbit Anti-ERBB3 Recombinant Antibody (TAB-060CT) | Inhib, ELISA | Rabbit IgG |
| TAB-064CT | Mouse Anti-ERBB3 Recombinant Antibody (TAB-064CT) | ELISA, FC | Mouse IgG |
| TAB-067CT | Anti-Human HER3 Recombinant Antibody (5101) | ELISA, Inhibition, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
| TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
| TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-063CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-063CT-S(P)) | ELISA, Inhib, FC | Human scFv |
| TAB-057CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-057CT-F(E)) | Inhibion, ELISA | Humanized Fab |
| TAB-058CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-058CT-F(E)) | WB, ELISA, Inhib | Humanized Fab |
| TAB-059CT-F(E) | Anti-Human HER3 Recombinant Antibody Fab Fragment (LMAb3) | WB, ELISA, Inhibition, FC | Humanized antibody |
| TAB-063CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-063CT-F(E)) | ELISA, Inhib, FC | Humanized Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
| NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
| NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
| NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone M908) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0286-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0287-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0288-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1126); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0289-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 12511); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0290-YC-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0290-YC-F(E)) | ELISA, FuncS, FC | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
| AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0090-WJ-S(P) | Mouse Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0090-WJ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0438-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 993); scFv Fragment | FC, Inhib | Mouse scFv |
| HPAB-1695-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-1695-FY-F(E)) | ELISA | Human Fab |
| HPAB-1696-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-1696-FY-F(E)) | ELISA | Human Fab |
| FAMAB-0047JF-S(P) | Human Anti-ERBB3 Recombinant Antibody (clone PM6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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