Anti-HIV-1 antibody is a Human antibody of IgG3 λ class that binds to an HIV-1. This antibody recognizes the hypervariable gp120 V3 loop, and neutralizes both X4 and R5 primary isolates, making it one of the most effective anti-V3 antibodies characterized to date.
Figure 1 Binding of the mutated 447-52D IgG to the indicated gp140 trimers as measured by ELISA.
McGuire, A. T., Glenn, J. A., Lippy, A., & Stamatatos, L. (2014). Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D. Journal of virology, 88(5), 2645-2657.
Figure 2 The area under the curve of the Ca2 flux response (determined in panel C) through the mutated 447-52D BCR correlates with the affinity of sIgG 447-52D (determined in panel A).
McGuire, A. T., Glenn, J. A., Lippy, A., & Stamatatos, L. (2014). Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D. Journal of virology, 88(5), 2645-2657.
Figure 3 Neutralization of chimeric psVs by antibodies 447-52D (purple) and 2219 (blue).
The psV consist of the SF162 strain with its V3 loop replaced by the indicated V3 loop sequence. Consensus B-R18Q is a psV consisting of the consensus subtype B V3 loop sequence with position 18 in the V3 loop mutated from a subtype B consensus arginine to a subtype C consensus glutamine. IC50 is the amount of antibody in ug/mL required to achieve 50% neutralization.
The negative base 10 logarithm of the IC50 has been plotted
for easier comparison: higher, positive bars towards the top of the
graph indicate strong neutralization by the antibody. Antibodies
were only tested to a concentration of 20 ug/mL for neutralization,
so the negative value of 1.3 on the plot is maximal and indicated no
detectable neutralization by the antibody
Almond, D., Krachmarov, C., Swetnam, J., Zolla-Pazner, S., & Cardozo, T. (2012). Resistance of subtype C HIV-1 strains to anti-V3 loop antibodies. Advances in virology, 2012.
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• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
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CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-541 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b13); Fab Fragment | Neut | Human Fab |
PFBL-543 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247); Fab Fragment | Neut | Humanized Fab |
PFBL-546 | Human Anti-HIV-1 gp120 V1V2 domain Recombinant Antibody (clone P4); Fab Fragment | WB, IF, FuncS | Human Fab |
PFBL-547 | Human Anti-HIV-1 gp120 V1V2 domain Recombinant Antibody (clone PG10); Fab Fragment | WB, IF, FuncS | Human Fab |
PSBZ-164 | Human Anti-HIV-1 gp120 Recombinant Antibody; scFv Fragment (PSBZ-164) | Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (D59/A2) | ELISA | Mouse antibody |
MRO-042LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (F58/H3) | ELISA | Mouse antibody |
MRO-043LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P1/D12) | ELISA | Mouse antibody |
MRO-044LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P4/D10) | ELISA | Mouse antibody |
MRO-045LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3559CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone HF1.7) | Neut | Mouse IgM |
MRO-3560CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone C2EB5) | ELISA, Neut | Mouse IgG |
MRO-3561CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone CA1 (ARP3117)) | ELISA, WB | Mouse IgG |
MRO-3562CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone CG-10 (CG10)) | Neut | Mouse IgG1 |
MRO-3563CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone CG-25) | Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3339CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone H003489 (3489)); scFv Fragment | ELISA, IF, FC, Neut | Human scFv |
MRO-3340CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone vc813DB); scFv Fragment | ELISA, Neut | Human scFv |
MRO-3341CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC13 (44-VRC13.01)); scFv Fragment | Neut | Human scFv |
MRO-3342CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC16 (C38-VRC16.01)); scFv Fragment | Neut | Human scFv |
MRO-3343CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC22); scFv Fragment | Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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