Anti-HIV-1 antibody (Fab2558) is a human antibody of IgG class that binds to an HIV-1.
Figure 1 Measurement of Env incorporation by Western blot.
WT and mutant viruses were produced in transfected 293T cells, lysed, and analyzed by SDS-PAGE (4±20%) and Western blot. An anti-gp120 MAb cocktail (V3: 391/95-D, 694/98-D, 2219, 2558; C2: 847-D, 1006-30D; C5: 450-D, 670-D) and a p24 Gag MAb (91±5) were used to detect the relative levels of Env and Gag associated with virions. The ratios of Env/Gag were calculated.
Upadhyay, C., Feyznezhad, R., Yang, W., Zhang, H., Zolla-Pazner, S., & Hioe, C. E. (2018). Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations. PLoS pathogens, 14(1), e1006812.
Figure 2 Structural similarity of the antigen-binding sites of VH5-51 encoded anti-V3 mAbs.
(A) A structural superimposition of the Ca atoms of the Fab variable domains of complexes 1006/MN (green), 2219/MN (cyan), 2557/NY5 (magenta), 2558/MN (yellow), and 4025/ConA
(salmon). Note the domains of CDR H1, H2, L1 and L2 superimposed well, while that of CDR L3 and H3 is more structurally divergent. (B) Same superimposition as that in panel (A) but with the key contact residues of the mAbs labeled (all contact residues are shown in Tables 4 and 5). The position of the V3 is illustrated as a dashed line. (C) and (D) Structural details of the antigen combining sites of the light (C) and heavy chains (D) in the five complexes.
Gorny, M. K., Sampson, J., Li, H., Jiang, X., Totrov, M., Wang, X. H., ... & Cardozo, T. (2011). Human anti-V3 HIV-1 monoclonal antibodies encoded by the VH5-51/VL lambda genes define a conserved antigenic structure. PloS one, 6(12), e27780.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1889-sdAb | Recombinant Anti-HIV-1 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
PNBL-038 | Recombinant Anti-HIV-1 C186 gp120 VHH Single Domain Antibody (A12) | WB, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-068 | Anti-HIV-1 Recombinant Antibody (Suvizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
PABX-094-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (Fab4025) | WB, ELISA, FuncS | scFv |
PABX-099-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment | FC, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G037E | Anti-HIV-1 immunotoxin 3B3 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G037D | Anti-HIV-1 immunotoxin 3B3 (scFv)-DT | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25); scFv Fragment | WB, ELISA, Neut, FuncS | Human scFv |
FAMAB-0176CQ-S(P) | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10); scFv Fragment | ELISA, Neut | Mouse scFv |
HPAB-0158-YJ-S(P) | Mouse Anti-HIV-1 Recombinant Antibody; scFv Fragment (HPAB-0158-YJ-S(P)) | ELISA, Neut, Inhib | Mouse scFv |
HPAB-AP363-YC-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone A2); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1989-FY-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone 9F11); scFv Fragment | FC, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
HPAB-0158-YJ-F(E) | Human Anti-HIV-1 Recombinant Antibody; Fab Fragment (HPAB-0158-YJ-F(E)) | ELISA, Neut, Inhib | Human Fab |
HPAB-AP363-YC-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone A2); Fab Fragment | ELISA, Neut | Human Fab |
HPAB-1988-FY-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone 2G9); Fab Fragment | FC, ELISA | Human Fab |
HPAB-1989-FY-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone 9F11); Fab Fragment | FC, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-770CQ | Mouse Anti-HIV-1 Recombinant Antibody (clone 10 (03-002)) | EIA, WB, IHC, IP | Mouse IgG1 |
FAMAB-0176CQ | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10) | ELISA, Neut | Mouse IgG |
VS-0423-XY8 | Mouse Anti-HIV-1 Recombinant Antibody (clone CP503) | ELISA | Mouse IgG |
VS-0423-XY9 | Mouse Anti-HIV-1 Recombinant Antibody (clone CP506) | ELISA | Mouse IgG |
VS-0423-XY10 | Mouse Anti-HIV-1 Recombinant Antibody (clone CP507) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-090 | Recombinant Human Anti-HIV-1 Antibody (CH04H/CH02L) | Neut, FuncS | IgG |
PABX-091 | Recombinant Human Anti-HIV-1 Antibody (Fab2219) | Neut, ELISA, FuncS | IgG |
PABX-094 | Recombinant Human Anti-HIV-1 Antibody (Fab4025) | WB, ELISA, FuncS | IgG |
PABX-096 | Recombinant Human Anti-HIV-1 Antibody (N12-i15) | WB, ELISA, IF, FuncS | IgG |
PABX-095-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab59.1) | Neut, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-001-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (1281) | WB, FuncS | scFv |
PABX-084-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (83.1) | WB, ELISA, FuncS | Fab |
PABX-089-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (A10F9) | Neut, FuncS | Fab |
PABX-093-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (Fab28) | WB, ELISA, FuncS | Fab |
PABX-095-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (Fab59.1) | Neut, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-093-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab28) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1376 | PE-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1377 | APC-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1378 | BV421-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4221 | Rabbit Anti-HIV-1 Recombinant Antibody (clone SI300DS) | ELISA, ICC, IF, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-068 | Afuco™ Anti-HIV-1 ADCC Recombinant Antibody (Suvizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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