This product is a recombinant human anti-HIV-1 monoclonal antibody. CH08 specifically binds to gp120 and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Figure 1 HIV-1 pseudovirus neutralization by mAbs CH07 and CH08.
A panel of tier 1 and tier 2 HIV-1 pseudoviruses were tested against mAbs CH07, CH08, 17b, and 412-D in TZM-bl cells. CH07 weakly neutralized a single virus (92TH023.CRF01_AE). In contrast, CH08 neutralized multiple tier 1 and tier 2 viruses in a pattern similar to that of CD4i mAbs 17b and 412-D. A fragment (Fab) of CH08 neutralized with a potency similar to that of the intact mAb, suggesting that the binding site for mAb CH08 was not inaccessible for most of the isolates tested. An additional panel of 13 tier 2 viruses was not neutralized by any mAb tested.
Isolation of HIV-1-Neutralizing Mucosal Monoclonal Antibodies from Human Colostrum
Figure 2 ADCC and virus capture by mAbs CH07 and CH08.
CH07 and CH08 were tested for ADCC activity compared with anti-RSV mAb (Palivizumab) and A32. CH07 did not mediate ADCC, while both A32 and CH08 stimulated granzyme B activity NK effector cells when reacted with infected and gp120-coated targets. Each bar represents the percent of target cells containing granzyme B.
Isolation of HIV-1-Neutralizing Mucosal Monoclonal Antibodies from Human Colostrum
Figure 3 MAb CH08 is a CD4i HIV Env-specific antibody.
CH08 mAb binding to gp140Con.S after capture by mAb T8 (HIV gp120-specific mAb), soluble CD4 (sCD4), or mAb A32 (CD4 binding site mAb) was measured by SPR.
Isolation of HIV-1-Neutralizing Mucosal Monoclonal Antibodies from Human Colostrum
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABZ-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 50.1) | Neut | Mouse IgG2a, κ |
PABL-520 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 44-VRC13.01) | Neut | Human IgG |
PABL-521 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 45-46M2) | ELISA, Neut | Human IgG |
PABL-522 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 45-VRC01.H5.F-185917) | WB, FuncS | Human IgG |
PABL-523 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 8ANC131) | WB, FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC | Anti-HIV-1 gp120 Recombinant Antibody (D59/A2) | ELISA | Mouse antibody |
MRO-042LC | Anti-HIV-1 gp120 Recombinant Antibody (F58/H3) | WB, ELISA | Mouse antibody |
MRO-043LC | Anti-HIV-1 gp120 Recombinant Antibody (P1/D12) | ELISA | Mouse antibody |
MRO-044LC | Anti-HIV-1 gp120 Recombinant Antibody (P4/D10) | ELISA | Mouse antibody |
MRO-045LC | Anti-HIV-1 gp120 Recombinant Antibody (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-162LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-162LC) | ELISA, FC, Neut, SPR | Human IgG1, κ |
MRO-164LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-164LC) | ELISA | Human IgG1, κ |
MRO-165LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-165LC) | ELISA | Human IgG1, κ |
MRO-166LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-166LC) | ELISA, FuncS, FC, Neut | Human IgG1, κ |
MRO-167LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-167LC) | ELISA | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3262CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PCDN-33A (33A)); Fab Fragment | ELISA, Neut | Human Fab |
MRO-3263CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PCDN-16A (16A)); Fab Fragment | ELISA, Neut | Human Fab |
MRO-3264CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PCDN-27D (27D)); Fab Fragment | ELISA, Neut | Human Fab |
MRO-3265CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH13); Fab Fragment | ELISA, Neut | Human Fab |
MRO-3266CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH16); Fab Fragment | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0202CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CAP228-16H); scFv Fragment | ELISA, Neut | Human scFv |
FAMAB-0056WJ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L17); scFv Fragment | ELISA, Neut | Human scFv |
FAMAB-0057WJ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L69); scFv Fragment | ELISA, Neut | Human scFv |
FAMAB-0058WJ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone P20); scFv Fragment | ELISA, Neut | Human scFv |
PSBS-0130 | Human Anti-HIV-1 gp120 Recombinant Antibody (Clone VRC01cHuGL2); scFv Fragment | ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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