Recombinant Human Antibody (2G12) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp120 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This neutralizing human antibody recognizes terminal Man 1-2Man–linked moieties, contributed by oligomannose-type sugars that form a cluster on the silent face of gp120.
Figure 1 Human Anti-HIV-1 gp120 Antibody (2G12) in Neut.
Inhibition of the binding of 2G12 mAb to HIV-1-infected MT-4 cells in the presence of GNA, HHA and CV-N. MT-4 cells infected with HIV-1 strains IIIB (left panel), MN (middle panel) and NDK (right panel), were incubated with 2G12 mAb in the absence (red histograms) or presence of different concentrations of GNA (green histograms), HHA (orange histograms) and CV-N (light blue). The dark blue histograms show the background fluorescence. The mean fluorescence intensity (MFI) values are indicated in each histogram.
Schols, D. (2010). Microvirin, a novel (1, 2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile. proteins, 1, 3.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-541 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b13); Fab Fragment | Neut | Human Fab |
PFBL-543 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247); Fab Fragment | Neut | Humanized Fab |
PFBL-546 | Human Anti-HIV-1 gp120 V1V2 domain Recombinant Antibody (clone P4); Fab Fragment | WB, IF, FuncS | Human Fab |
PFBL-547 | Human Anti-HIV-1 gp120 V1V2 domain Recombinant Antibody (clone PG10); Fab Fragment | WB, IF, FuncS | Human Fab |
PFBL-548 | Human Anti-HIV-1 gp120 V1V2 region Recombinant Antibody (clone 830A); Fab Fragment | WB, IF, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC | Anti-HIV-1 gp120 Recombinant Antibody (D59/A2) | ELISA | Mouse antibody |
MRO-042LC | Anti-HIV-1 gp120 Recombinant Antibody (F58/H3) | WB, ELISA | Mouse antibody |
MRO-043LC | Anti-HIV-1 gp120 Recombinant Antibody (P1/D12) | ELISA | Mouse antibody |
MRO-044LC | Anti-HIV-1 gp120 Recombinant Antibody (P4/D10) | ELISA | Mouse antibody |
MRO-045LC | Anti-HIV-1 gp120 Recombinant Antibody (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-162LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-162LC) | ELISA, FC, Neut, SPR | Human IgG1, κ |
MRO-164LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-164LC) | ELISA | Human IgG1, κ |
MRO-165LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-165LC) | ELISA | Human IgG1, κ |
MRO-166LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-166LC) | ELISA, FuncS, FC, Neut | Human IgG1, κ |
MRO-167LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-167LC) | ELISA | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3568CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone D24); scFv Fragment | ELISA, Block | Mouse scFv |
MRO-3569CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone D25); scFv Fragment | ELISA, Block | Mouse scFv |
MRO-3570CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone D27); scFv Fragment | ELISA, Block | Mouse scFv |
MRO-3571CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone D47); scFv Fragment | ELISA | Mouse scFv |
MRO-3572CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone D56); scFv Fragment | ELISA, Neut | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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