Recombinant Human Antibody (Z258-VRC27.01) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp160 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp160 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody neutralized 78% of HIV-1 strains.
Figure 1 Flow cytometric identification of RSC3-reactive IgG+ B cells from a donor (donor Z258).
Gating and percentage of antigen-specific (RSC3+, ΔRSC3-) memory B cells (CD19+, CD20+, IgG+) are indicated. Sorted cells are in light gray while VRC27.01 and its respective clonal relatives are highlighted by colored dots.
Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A., ... & Ernandes, M. J. (2015). Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell, 161(6), 1280-1292.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-177 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-177) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-178 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 3H+109L) | WB, ELISA, FuncS | Human IgG |
PABL-179 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128) | WB, ELISA, FuncS | Human IgG |
PABL-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C) | WB, ELISA, Neut, FuncS | Human IgG, κ |
PABL-181 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01) | FC, Neut, FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-177 | Human Anti-HIV-1 gp160 Recombinant Antibody; scFv Fragment (PSBL-177) | WB, ELISA, Neut, FuncS | Human scFv |
PSBL-178 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 3H+109L); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBL-179 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBL-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C); scFv Fragment | WB, ELISA, Neut, FuncS | Human scFv |
PSBL-181 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01); scFv Fragment | FC, Neut, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-382 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08); Fab Fragment | Neut, FuncS | Human Fab |
MRO-3673CQ-F(E) | Chimpanzee Anti-HIV-1 gp160 Recombinant Antibody (clone C311E); Fab Fragment | Neut | Chimpanzee Fab |
MRO-3674CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone HGN35); Fab Fragment | ELISA | Human Fab |
MRO-3675CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 10-188); Fab Fragment | ELISA, Neut | Human Fab |
MRO-3676CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 10-380); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-075LC | Anti-HIV-1 gp160 Recombinant Antibody (24G3) | WB, ELISA | Human antibody |
MRO-080LC | Anti-HIV-1 gp160 Recombinant Antibody (81C7) | ELISA | Human antibody |
MRO-091LC | Anti-HIV-1 gp160 Recombinant Antibody (MAb CL1) | ELISA | Human antibody |
MRO-100LC | Anti-HIV-1 gp160 Recombinant Antibody (N7019b) | ELISA | Human antibody |
MRO-101LC | Anti-HIV-1 gp160 Recombinant Antibody (K24-3b) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
MRO-088LC | Anti-HIV-1 gp160 Recombinant Antibody (2D7) | ELISA | Mouse antibody |
MRO-089LC | Anti-HIV-1 gp160 Recombinant Antibody (2H8) | ELISA | Mouse antibody |
MRO-086LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1C1) | ELISA | Mouse antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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