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Anti-HIV-1 immunotoxin 3B3 (scFv)-DT (AGTO-G037D)

This immunotoxin was achieved by conjugating/fusing the Anti-HIV-1 scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to infected cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of immunodeficiency virus type 1 (HIV-1) infection.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
3B3
Molecule Class
scFv-DT
Toxin Description
Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
immunodeficiency virus type 1 (HIV-1) infection
Target
Alternative Names
HIV; human immunodeficiency virus; acquired immunodeficiency syndrome; AIDS; HIV-1; human immunodeficiency virus type 1; Diphtheria toxin; Diphtheria-toxin

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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