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Anti-HIV gp120 Intrabody [(D-Arg)9] (IAB-B053(A))

Recombinant anti-HIV gp120 intrabody linked to (D-Arg)9 works within cells and specifically reacts with HIV gp120, expressed in E. coli cells.      

Specifications
Immunogen
human papillomavirus gp120
Host
human
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
HIV
Applications
Can be useful in applications such as: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies
Target
Alternative Names
HIV gp120; Envelope glycoprotein GP120; gp120; GP120; Glycoprotein 120

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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