Anti-Human HLA-DR β Recombinant Antibody (1D09C3) (CAT#: TAB-095CT)

Recombinant monoclonal antibody 1D09C3 to HLA-DR β. This antibody intended for the prophylaxis and treatment studies of Rheumatoid arthritis and Multiple sclerosis.


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Inhib

Figure 1 1D09C3 induces time- and dose-dependent cell death of HLA-DR+ cell lines.

Figure 1 1D09C3 induces time- and dose-dependent cell death of HLA-DR+ cell lines.

Dose-dependent cell death of JVM-2 cells.

Carlo-Stella, C., Di Nicola, M., Turco, M. C., Cleris, L., Lavazza, C., Longoni, P., ... & Nagy, Z. (2006). The Anti–Human Leukocyte Antigen-DR Monoclonal Antibody 1D09C3 Activates the Mitochondrial Cell Death Pathway and Exerts a Potent Antitumor Activity in Lymphoma-Bearing Nonobese Diabetic/Severe Combined Immunodeficient Mice. Cancer Research, 66(3), 1799-1808.

WB

Figure 2 JVM-2 and GRANTA-519 cells were treated with 1D09C3 (10 μg/mL) for 4 to 24 hours.

Figure 2 JVM-2 and GRANTA-519 cells were treated with 1D09C3 (10 μg/mL) for 4 to 24 hours.

Cytosolic proteins were then separated by SDS-PAGE and analyzed by immunoblotting with anti-caspase-8. No processing of the caspases or PARP was observed. CF, cleaved fragments.

Carlo-Stella, C., Di Nicola, M., Turco, M. C., Cleris, L., Lavazza, C., Longoni, P., ... & Nagy, Z. (2006). The Anti–Human Leukocyte Antigen-DR Monoclonal Antibody 1D09C3 Activates the Mitochondrial Cell Death Pathway and Exerts a Potent Antitumor Activity in Lymphoma-Bearing Nonobese Diabetic/Severe Combined Immunodeficient Mice. Cancer Research, 66(3), 1799-1808.

FC

Figure 3 1D09C3 induces mitochondrial depolarization and generation of ROS.

Figure 3 1D09C3 induces mitochondrial depolarization and generation of ROS.

GRANTA-519 cells were plated at 1 × 10⁶/mL and incubated with 1D09C3 (10 μg/mL). At the indicated time points, loss of mitochondrial potential was measured using TMRE staining and flow cytometry.

Carlo-Stella, C., Di Nicola, M., Turco, M. C., Cleris, L., Lavazza, C., Longoni, P., ... & Nagy, Z. (2006). The Anti–Human Leukocyte Antigen-DR Monoclonal Antibody 1D09C3 Activates the Mitochondrial Cell Death Pathway and Exerts a Potent Antitumor Activity in Lymphoma-Bearing Nonobese Diabetic/Severe Combined Immunodeficient Mice. Cancer Research, 66(3), 1799-1808.

IHC

Figure 4 IFN-γ up-regulates HLA-DR expression in vivo and enhances the therapeutic activity of 1D09C3.

Figure 4 IFN-γ up-regulates HLA-DR expression in vivo and enhances the therapeutic activity of 1D09C3.

Anti-human HLA-DR staining of sections from tumornodules growing in mice injected s.c. with KMS-11 cell line. Tumor nodules (10 mm in diameter) were excised and stained 24 h after injection of IFN-γ (10⁴ IU/mouse; i.p.; days 1, 2, and 3; magnification ×40).

Carlo-Stella, C., Guidetti, A., Di Nicola, M., Lavazza, C., Cleris, L., Sia, D., ... & Corradini, P. (2007). IFN-γ enhances the antimyeloma activity of the fully human anti–human leukocyte antigen-DR monoclonal antibody 1D09C3. Cancer research, 67(7), 3269-3275.


Specifications

  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • 1D09C3
  • Applications
  • FC, Inhib, WB, IHC
  • Related Disease
  • Rheumatoid arthritis and Multiple sclerosis.

Applications

  • Application Notes
  • This antibody has been reported for use in Flow Cytometry, Inhibition, Western Blot and Immunohistochemistry.

Target

  • Alternative Names
  • HLA-DR; Human Leukocyte Antigen-DR; L243

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Humanized Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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