Afuco™ Anti-Human HPSE ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-351CL)
Anti-HPSE ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This is a fully human antibody that binds to and neutralizes the heparanase I enzyme. Preclinical testing suggests that this antibody has the potential to prevent tumor growth and to reduce metastasis to limit the spread of tumors. This antibody to heparanase I, one of a family of heparanase molecules, has the potential to be used in the treatment of many tumors, including breast cancer.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55344/874_A7_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55344/874_A7_1_red_green.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & Vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55344/886_H3_2_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & Vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55344/886_H3_2_red_green.jpg
Figure 3 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55344/881_A7_1_red_green.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55344/881_A7_1_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (Karpas-707, OE19, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000173083-HPSE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000173083-HPSE
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Breast Cancer
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- HPSE; heparanase; HPA; HPA1; HPR1; HSE1; HPSE1; heparanase-1; endo-glucoronidase
- Gene ID
- 10855
- UniProt ID
- Q9Y251
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HPSE"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-673-sdAb | Recombinant Anti-human HPSE VHH Single Domain Antibody | FUNC, FA, IP, ChiP | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-025CT | Anti-Human Heparanase Recombinant Antibody (10E9.1) | ELISA, Inhibition, FC | Human antibody |
| TAB-025CT-S(P) | Anti-Human Heparanase Recombinant Antibody scFv Fragment (10E9.1) | ELISA, Inhibition, FC | Human antibody |
| TAB-025CT-F(E) | Anti-Human Heparanase Recombinant Antibody Fab Fragment (10E9.1) | ELISA, Inhibition, FC | Human antibody |
| TAB-280CQ-S(P) | Anti-Human HPSE Recombinant Antibody scFv Fragment (22D9) | ELISA, FC, WB | Human antibody |
| TAB-280CQ-F(E) | Anti-Human HPSE Recombinant Antibody Fab Fragment (22D9) | ELISA, FC, WB | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0628CT | Recombinant Mouse anti-Human HPSE Monoclonal antibody (EML1141) | WB | |
| HPAB-0264-YC | Mouse Anti-HPSE Recombinant Antibody (HPAB-0264-YC) | WB, IF | Mouse IgM |
| HPAB-0265-YC | Mouse Anti-HPSE Recombinant Antibody (HPAB-0265-YC) | FC, Neut, FuncS | Mouse IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1672 | Rabbit Anti-HPSE Recombinant Antibody (clone DS1672AB) | WB, IP | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0264-YC-S(P) | Mouse Anti-HPSE Recombinant Antibody; scFv Fragment (HPAB-0264-YC-S(P)) | FC, Neut, FuncS | Mouse scFv |
| HPAB-0265-YC-S(P) | Mouse Anti-HPSE Recombinant Antibody; scFv Fragment (HPAB-0265-YC-S(P)) | FC, Neut, FuncS | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0264-YC-F(E) | Mouse Anti-HPSE Recombinant Antibody; Fab Fragment (HPAB-0264-YC-F(E)) | FC, Neut, FuncS | Mouse Fab |
| HPAB-0265-YC-F(E) | Mouse Anti-HPSE Recombinant Antibody; Fab Fragment (HPAB-0265-YC-F(E)) | FC, Neut, FuncS | Mouse Fab |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0853 | PE-A*02:01/Human HPSE (LLLGPLGPL) MHC Tetramer | FCM, IHC | |
| MHC-CN0854 | APC-A*02:01/Human HPSE (LLLGPLGPL) MHC Tetramer | FCM, IHC | |
| MHC-CN0855 | FITC-A*02:01/Human HPSE (LLLGPLGPL) MHC Tetramer | FCM, IHC | |
| MHC-CN0856 | A*02:01/Human HPSE (LLLGPLGPL) MHC Tetramer | FCM, IHC | |
| MHC-YF472 | A*02:01/Human Heparanase (ALPPPLMLL) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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