Products

Anti-HPV16 E7 Intrabody [(D-Arg)9] (IAB-B047(A))

Recombinant anti-HPV16 E7 intrabody linked to (D-Arg)9 works within cells and specifically reacts with HPV16 E7, expressed in 293T cells. The intrabody is specific for the E7 oncoprotein of HPV16 and is able to inhibit cell proliferation.      

Specifications
Immunogen
Human papillomavirus16 transforming protein
Host
mouse
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
HPV16
Applications
Products can be used for: Immunocytochemistry; Neutralization; Functional studies
Target
Alternative Names
E7; transforming protein
Entrez Gene ID
1489079
UniProt ID
P03129

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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