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Anti-HPV16 E7 Intrabody [Tat] (IAB-B047(T))

Recombinant anti-HPV16 E7 intrabody in fusion with HIV Tat works within cells to bind HPV16 E7, expressed in 293T cells. The intrabody is specific for the E7 oncoprotein of HPV16 and is able to inhibit cell proliferation.      

Specifications
Immunogen
Human papillomavirus16 transforming protein
Host
mouse
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
HPV16
Applications
Formats of immunological tests: Immunofluorescence; Flow Cytometry; Western blot; Functional studies
Target
Alternative Names
E7; transforming protein
Entrez Gene ID
1489079
UniProt ID
P03129

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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