Anti-Human C5 Recombinant Antibody (Eculizumab) (CAT#: TAB-008)
Recombinant monoclonal antibody to Human C5. Eculizumab also is the first agent approved for the treatment of atypical hemolytic uremic syndrome (aHUS), an ultra-rare genetic disease that causes abnormal blood clots to form in small blood vessels throughout the body, leading to kidney failure, damage to other vital organs and premature death.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
Specifications
- Immunogen
- Human C5 protein emulsified with complete Fraud`s adjuvant
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG2 / G4 - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
- Trade name
- soliris
- CAS
- 219685-50-4
- Generic Name
- Eculizumab
- Biological Half-Life
- 8 to 15 days (mean 11 days)
- ATC Code
- L04AA25
- DrugBank
- DB01257
- UNII
- A3ULP0F556
- ChEMBL
- CHEMBL1201828
- MW
- 148 kDa
- Related Disease
- Neuromyelitis optica (NMO)
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- Eculizumab;soliris;219685-50-4;h5G1.1;DB01257 C5;complement component 5;complement C5;CPAMD4;anaphylatoxin C5a analog;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4;FLJ17816;FLJ17822;MGC142298;
- Gene ID
- 727
- UniProt ID
- P01031
Related Resources
Please refer to Eculizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Eculizumab.
Systemic Lupus Erythematosus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Eculizumab"
Afuco™ Anti-C5 ADCC Recombinant Antibody (Eculizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human C5. Eculizumab also is the first agent approved for the treatment of atypical hemolytic uremic syndrome (aHUS), an ultra-rare genetic disease that causes abnormal blood clots to form in small blood vessels throughout the body, leading to kidney failure, damage to other vital organs and premature death.
See other products for "C5"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-934 | Recombinant Human Anti-C5 Antibody scFv Fragment | ELISA, SPR, Inhib | scFv |
| HPAB-0609-CN-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0609-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-1794LY-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-1794LY-S(P)) | ELISA, Block | Human scFv |
| HPAB-1795LY-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-1795LY-S(P)) | ELISA, Block | Human scFv |
| HPAB-1796LY-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-1796LY-S(P)) | ELISA, Block | Human scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-084CL | Human Anti-C5 Recombinant Antibody (TAB-084CL) | ELISA, FuncS, Inhib | Human IgG |
| TAB-1372CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1372CL-S(P)) | Inhib, FuncS | Human scFv |
| TAB-1373CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1373CL-S(P)) | IB, Inhib | Humanized scFv |
| TAB-1374CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1374CL-S(P)) | ELISA, Inhib | Humanized scFv |
| TAB-1375CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1375CL-S(P)) | ELISA, Inhib | Humanized scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1366CL | Mouse Anti-C5 Recombinant Antibody (TAB-1366CL) | ELISA, Inhib | Mouse IgG |
| TAB-1367CL | Mouse Anti-C5 Recombinant Antibody (TAB-1367CL) | ELISA, Inhib | Mouse IgG |
| TAB-1368CL | Mouse Anti-C5 Recombinant Antibody (TAB-1368CL) | ELISA | Mouse IgG |
| TAB-1369CL | Mouse Anti-C5 Recombinant Antibody (TAB-1369CL) | ELISA, Inhib | Mouse IgG |
| TAB-1370CL | Mouse Anti-C5 Recombinant Antibody (TAB-1370CL) | ELISA | Mouse IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-082CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL249) | ELISA, Neut | Mouse IgG2a |
| NEUT-083CQ | Mouse Anti-C5 Recombinant Antibody (clone MM0608-6H13) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-084CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL030) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-085CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL250) | ELISA, WB, IHC, FuncS | Mouse IgG1 |
| NEUT-086CQ | Mouse Anti-C5 Recombinant Antibody (clone G25/2) | ELISA, IP, WB, Neut | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-088CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL771) | WB, Block, ELISA | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4104 | Hi-Affi™ Rabbit Anti-C5 Recombinant Antibody (clone SI175DS) | IHC-P | Rabbit IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-453CQ | Anti-Human C5 Recombinant Antibody (Tesidolumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ2 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0613-CN-F(E) | Human Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0613-CN-F(E)) | WB, ELISA, FC | Humanized Fab |
| HPAB-0614-CN-F(E) | Mouse Anti-C5 Recombinant Antibody (clone m5G1.1); Fab Fragment | WB, ELISA, IF, IP, Block | Mouse Fab |
| HPAB-0615-CN-F(E) | Human Anti-C5 Recombinant Antibody (clone 5G1.1CB); Fab Fragment | WB, ELISA, IF, IP | Humanized Fab |
| HPAB-0123-LS-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0123-LS-F(E)) | Block, ELISA | Mouse Fab |
| HPAB-0124-LS-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0124-LS-F(E)) | Block, ELISA | Mouse Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0652LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0652LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0653LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0653LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0654LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0654LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0655LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0655LY) | IP, RIA, ELISA, WB | Mouse IgG |
| HPAB-0656LY | Mouse Anti-C5 Recombinant Antibody (HPAB-0656LY) | IP, RIA, ELISA, WB | Mouse IgG |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-559 | Recombinant Llama Anti-C5 Single Domain Antibody (Nb36) | ELISA | Llama VHH |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-453CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody (Tesidolumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-008 | Afuco™ Anti-C5 ADCC Recombinant Antibody (Eculizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-436CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody (Olendalizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for TAB-008. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.