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Abagovomab (TAB-114)

Recombinant monoclonal antibody to CA-125. Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA-125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.      

Specifications
Immunogen
CA-125 purified from human ovarian carcinoma.
Host
Mouse
Derivation
Mouse
Type
IgG1 - kappa
Specificity
Tested positive against native human antigen.
Species Reactivity
Human
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
CAS NO.
792921-10-9
Generic Name
Abagovomab
UNII
3YK0326U7X
Related Disease
Ovarian cancers
Target
Alternative Names
Abagovomab; 792921-10-9; OC125; ACA125; clone 3D5; MUC16; mucin 16, cell surface associated; mucin-16
Entrez Gene ID
94025
UniProt ID
Q8WXI7

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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