Products

Ibritumomab (TAB-001)

Recombinant monoclonal antibody to Human CD20. Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for relapsed or refractory, low grade or transformed B cell non-Hodgkin's lymphoma, a lymphoproliferative disorder and thus affects the lymphatic system. The drug uses the monoclonal mouse IgG1 antibody ibritumomab (pronounced as ) in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group      

Specifications
Immunogen
Human lymphoblastoid cell line SB
Host
Mouse
Derivation
Mouse
Type
IgG1 - kappa
Specificity
Tested positive against native human antigen
Species Reactivity
Human
Applications
Suitable for use in ELISA, western blot, immunohistochemistry, flow cytometry, immunoaffinity purification and most other immunological methods. ELISA, IP, FC, FuncS, IF, Neut and most other immunological methods.
Trade name
zevalin
CAS NO.
174722-31-7
Generic Name
Ibritumomab
ATC Code
V10XX02 (90Y)
DrugBank
DB00078
UNII
4Q52C550XK
ChEMBL
CHEMBL1201606
Target
Alternative Names
Ibritumomab; zevalin; 174722-31-7; Zevalin; Ibritumomab ; DB00078MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20
Entrez Gene ID
931
UniProt ID
P11836

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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